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. 1988 Aug;41(8):866–870. doi: 10.1136/jcp.41.8.866

Prognostic indicators in centroblastic-centrocytic lymphoma.

N R Griffin 1, M R Howard 1, P Quirke 1, C J O'Brien 1, J A Child 1, C C Bird 1
PMCID: PMC1141617  PMID: 3170773

Abstract

The prognostic importance of ploidy and proliferative index (%S + G2) assessed by flow cytometry, mitotic and centroblast counts, and histological growth pattern were evaluated in biopsy specimens taken before treatment from 60 cases of centroblastic-centrocytic non-Hodgkin's lymphoma. Cases with a high proliferative index (greater than or equal to 18%) or DNA aneuploidy showed significantly poorer survival than those with a low proliferative index (less than 18%). A high mitotic count was also associated with a poor prognosis. On multiple regression analysis the flow cytometric assessments and mitotic counts were significant predictors of survival. Assessments of proliferative activity clearly have prognostic potential in centroblastic-centrocytic lymphoma and may permit more accurate characterisation of individual tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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