Abstract
A retrospective study of 211 bone marrow aspirates from patients with chronic myeloid leukaemia (CML) was undertaken to assess the incidence of Gaucher cells and sea-blue histiocytes. A significant correlation between the presence of these cells and prolonged survival was seen. Such storage histiocytes occurred most often during periods of relapsed chronic phase. This study shows that Gaucher cells and sea blue histiocytes are a common feature of CML and that their accumulation seems to be associated with a prolonged increase in leucocyte turnover.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dosik H., Rosner F., Sawitsky A. Acquired lipidosis: Gaucher-like cells and "blue cells" in chronic granulocytic leukemia. Semin Hematol. 1972 Jul;9(3):309–316. [PubMed] [Google Scholar]
- Gerdes J., Marathe R. L., Bloodworth J. M., MacKinney A. A., Jr Gaucher cells in chronic granulocytic leukemia. Arch Pathol. 1969 Aug;88(2):194–198. [PubMed] [Google Scholar]
- Kampine J. P., Brady R. O., Yankee R. A., Kanfer J. N., Shapiro D., Gal A. E. Sphingolipid metabolism in leukemic leukocytes. Cancer Res. 1967 Jul;27(7):1312–1315. [PubMed] [Google Scholar]
- Kattlove H. E., Williams J. C., Gaynor E., Spivack M., Bradley R. M., Brady R. O. Gaucher cells in chronic myelocytic leukemia: an acquired abnormality. Blood. 1969 Feb;33(2):379–390. [PubMed] [Google Scholar]
- Smith W. C., Kaneshiro M. M., Goldstein B. D., Parker J. W., Lukes R. J. Gaucher cells in chronic granulocytic leukaemia. Lancet. 1968 Oct 5;2(7571):780–781. doi: 10.1016/s0140-6736(68)90990-2. [DOI] [PubMed] [Google Scholar]