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. 1988 Dec;41(12):1249–1255. doi: 10.1136/jcp.41.12.1249

Mechanism of action of intravenous immunoglobulin in immune-mediated cytopenias.

H I Atrah 1, R J Davidson 1
PMCID: PMC1141755  PMID: 3066800

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Selected References

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  1. Arsura E. L., Bick A., Brunner N. G., Namba T., Grob D. High-dose intravenous immunoglobulin in the management of myasthenia gravis. Arch Intern Med. 1986 Jul;146(7):1365–1368. [PubMed] [Google Scholar]
  2. Atrah H. I., Crawford R. J. Blood group and response to immunoglobulin in immune thrombocytopenia. Lancet. 1984 Oct 6;2(8406):810–810. doi: 10.1016/s0140-6736(84)90730-x. [DOI] [PubMed] [Google Scholar]
  3. Atrah H. I., Crawford R. J., Gabra G. S., Forwell M. A., Mitchell R., Islam S. I., Ramsay D., Sandilands G. P. Modulation of suppressor T-cells for the treatment of aplastic anaemia. Lancet. 1985 Aug 10;2(8450):339–340. doi: 10.1016/s0140-6736(85)90393-9. [DOI] [PubMed] [Google Scholar]
  4. Atrah H. I., Crawford R. J., Gabra G. S., Mitchell R. Intravenous immunoglobulin therapy for idiopathic thrombocytopenic purpura. Scott Med J. 1986 Oct;31(4):231–233. doi: 10.1177/003693308603100404. [DOI] [PubMed] [Google Scholar]
  5. Atrah H. I., Sandilands G. P. A proposed mechanism of action for ALG and ATG in severe acquired aplastic anaemia. J Clin Lab Immunol. 1988 Feb;25(2):59–62. [PubMed] [Google Scholar]
  6. Atrah H. I., Templeton J. G., Crawford R. J., Gabra G. S., Mitchell R. Passive haemagglutination inhibition for quantitation of red cell associated IgG. J Clin Pathol. 1987 May;40(5):494–499. doi: 10.1136/jcp.40.5.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Augener W., Friedmann B., Brittinger G. Are aggregates of IgG the effective part of high-dose immunoglobulin therapy in adult idiopathic thrombocytopenic purpura (ITP)? Blut. 1985 Apr;50(4):249–252. doi: 10.1007/BF00320302. [DOI] [PubMed] [Google Scholar]
  8. BERGLUND G. Plasma transfusion treatment of six children with idiopathic thrombocytopenic purpura. Acta Paediatr. 1962 Sep;51:523–528. doi: 10.1111/j.1651-2227.1962.tb06578.x. [DOI] [PubMed] [Google Scholar]
  9. Bacigalupo A., Podestà M., Mingari M. C., Moretta L., Van Lint M. T., Marmont A. Immune suppression of hematopoiesis in aplastic anemia: activity of T-gamma lymphocytes. J Immunol. 1980 Oct;125(4):1449–1453. [PubMed] [Google Scholar]
  10. Baglin T. P., Smith M. P., Boughton B. J. Rapid and complete response of immune thrombocytopenic purpura to a single injection of rhesus anti-D immunoglobulin. Lancet. 1986 Jun 7;1(8493):1329–1330. doi: 10.1016/s0140-6736(86)91251-1. [DOI] [PubMed] [Google Scholar]
  11. Ball S., Zuiable A., Roter B. L., Hegde U. M. Changes in platelet immunoprotein levels during therapy in adult immune thrombocytopenia. Br J Haematol. 1985 Aug;60(4):631–633. doi: 10.1111/j.1365-2141.1985.tb07466.x. [DOI] [PubMed] [Google Scholar]
  12. Bierling P., Farcet J. P., Duedari N., Rochant H. Increase-platelet-associated IgG in patient on high-dose gammaglobulin for autoimmune thrombocytopenic purpura. Lancet. 1982 Aug 14;2(8294):388–388. doi: 10.1016/s0140-6736(82)90580-3. [DOI] [PubMed] [Google Scholar]
  13. Budde U., Auch D., Niese D., Schäfer G., Reske S. N., Schmidt R. E. Reticuloendothelial system Fc-receptor function in patients with immune thrombocytopenia after treatment with high dose intravenous immunoglobulin. Scand J Haematol. 1986 Aug;37(2):125–129. doi: 10.1111/j.1600-0609.1986.tb01785.x. [DOI] [PubMed] [Google Scholar]
  14. Bussel J. B., Hilgartner M. W. The use and mechanism of action of intravenous immunoglobulin in the treatment of immune haematologic disease. Br J Haematol. 1984 Jan;56(1):1–7. doi: 10.1111/j.1365-2141.1984.tb01266.x. [DOI] [PubMed] [Google Scholar]
  15. Bussel J. B., Kimberly R. P., Inman R. D., Schulman I., Cunningham-Rundles C., Cheung N., Smithwick E. M., O'Malley J., Barandun S., Hilgartner M. W. Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura. Blood. 1983 Aug;62(2):480–486. [PubMed] [Google Scholar]
  16. Bussel J. B., Pham L. C. Intravenous treatment with gammaglobulin in adults with immune thrombocytopenic purpura: review of the literature. Vox Sang. 1987;52(3):206–211. doi: 10.1111/j.1423-0410.1987.tb03029.x. [DOI] [PubMed] [Google Scholar]
  17. Bussel J. B., Schulman I., Hilgartner M. W., Barandun S. Intravenous use of gammaglobulin in the treatment of chronic immune thrombocytopenic purpura as a means to defer splenectomy. J Pediatr. 1983 Oct;103(4):651–654. doi: 10.1016/s0022-3476(83)80608-8. [DOI] [PubMed] [Google Scholar]
  18. Clauvel J. P., Vainchenker W., Herrera A., Dellagi K., Vinci G., Tabilio A., Lacombe C. Treatment of pure red cell aplasia by high dose intravenous immunoglobulins. Br J Haematol. 1983 Oct;55(2):380–382. doi: 10.1111/j.1365-2141.1983.tb01260.x. [DOI] [PubMed] [Google Scholar]
  19. Cocker J. E., Templeton G., Peel M. G., Crawford R. J., Crichton W. B., Sandilands G. P. Lymphocyte Fc gamma-receptor blocking antibodies in intravenous gammaglobulin preparations. J Clin Lab Immunol. 1987 Feb;22(2):85–90. [PubMed] [Google Scholar]
  20. Cohen L., Sharp S., Kulczycki A., Jr Human monocytes, B lymphocytes, and non-B lymphocytes each have structurally unique Fc gamma receptors. J Immunol. 1983 Jul;131(1):378–383. [PubMed] [Google Scholar]
  21. Cross A. S., Alving B. M., Sadoff J. C., Baldwin P., Terebelo H., Tang D. Intravenous immune globulin: a cautionary note. Lancet. 1984 Apr 21;1(8382):912–912. doi: 10.1016/s0140-6736(84)91376-x. [DOI] [PubMed] [Google Scholar]
  22. Dammacco F., Iodice G., Campobasso N. Treatment of adult patients with idiopathic thrombocytopenic purpura with intravenous immunoglobulin: effects on circulating T cell subsets and PWM-induced antibody synthesis in vitro. Br J Haematol. 1986 Jan;62(1):125–135. doi: 10.1111/j.1365-2141.1986.tb02908.x. [DOI] [PubMed] [Google Scholar]
  23. Delfraissy J. F., Tchernia G., Laurian Y., Wallon C., Galanaud P., Dormont J. Suppressor cell function after intravenous gammaglobulin treatment in adult chronic idiopathic thrombocytopenic purpura. Br J Haematol. 1985 Jun;60(2):315–322. doi: 10.1111/j.1365-2141.1985.tb07417.x. [DOI] [PubMed] [Google Scholar]
  24. Doskocil M., Med M., Vimmer T. Musculus rectus femoris--zacátecní slacha, její funkcní význam. Acta Chir Orthop Traumatol Cech. 1987 Apr;54(2):99–107. [PubMed] [Google Scholar]
  25. Durandy A., Fischer A., Griscelli C. Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy. J Clin Invest. 1981 Mar;67(3):867–877. doi: 10.1172/JCI110104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Emilia G., Sacchi S., Torelli G., Selleri L., Torelli U. Low-dose intravenous pepsin-treated gammaglobulin for idiopathic thrombocytopenic purpura in adults. Br J Haematol. 1984 Dec;58(4):761–762. doi: 10.1111/j.1365-2141.1984.tb06123.x. [DOI] [PubMed] [Google Scholar]
  27. Engelhard D., Waner J. L., Kapoor N., Good R. A. Effect of intravenous immune globulin on natural killer cell activity: possible association with autoimmune neutropenia and idiopathic thrombocytopenia. J Pediatr. 1986 Jan;108(1):77–81. doi: 10.1016/s0022-3476(86)80772-7. [DOI] [PubMed] [Google Scholar]
  28. FINKELSTEIN M. S., UHR J. W. SPECIFIC INHIBITION OF ANTIBODY FORMATION BY PASSIVELY ADMINISTERED 19S AND 7S ANTIBODY. Science. 1964 Oct 2;146(3640):67–69. doi: 10.1126/science.146.3640.67. [DOI] [PubMed] [Google Scholar]
  29. Fehr J., Hofmann V., Kappeler U. Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gamma globulin. N Engl J Med. 1982 May 27;306(21):1254–1258. doi: 10.1056/NEJM198205273062102. [DOI] [PubMed] [Google Scholar]
  30. Forwell M., Gray K. G., MacSween R. N., Peel M. G., Madhok R., Forbes C. D., Harvey J. A., Roberts J., Ferrell L., Sandilands G. P. Immunosuppression following alloantigen exposure: a role for lymphocyte Fc gamma-receptor blocking antibodies. J Clin Lab Immunol. 1986 Feb;19(2):53–57. [PubMed] [Google Scholar]
  31. Gilhus N. E., Matre R. Fc gamma receptors and HLA-DR antigens on thymus cells in myasthenia gravis. J Neuroimmunol. 1986 Jan;10(3):271–278. doi: 10.1016/0165-5728(86)90107-4. [DOI] [PubMed] [Google Scholar]
  32. Gross B., Haessig A., Luescher E. F., Nydegger U. E. Monomeric IgG preparations for intravenous use inhibit platelet stimulation by polymeric IgG. Br J Haematol. 1983 Feb;53(2):289–299. doi: 10.1111/j.1365-2141.1983.tb02023.x. [DOI] [PubMed] [Google Scholar]
  33. Imbach P., Barandun S., Baumgartner C., Hirt A., Hofer F., Wagner H. P. High-dose intravenous gammaglobulin therapy of refractory, in particular idiopathic thrombocytopenia in childhood. Helv Paediatr Acta. 1981 Feb;36(1):81–86. [PubMed] [Google Scholar]
  34. Imbach P., Barandun S., d'Apuzzo V., Baumgartner C., Hirt A., Morell A., Rossi E., Schöni M., Vest M., Wagner H. P. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet. 1981 Jun 6;1(8232):1228–1231. doi: 10.1016/s0140-6736(81)92400-4. [DOI] [PubMed] [Google Scholar]
  35. Imbach P., Jungi T. W. Possible mechanisms of intravenous immunoglobulin treatment in childhood idiopathic thrombocytopenic purpura (ITP). Blut. 1983 Mar;46(3):117–124. doi: 10.1007/BF00320269. [DOI] [PubMed] [Google Scholar]
  36. Jerne N. K. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 Jan;125C(1-2):373–389. [PubMed] [Google Scholar]
  37. Kawada K., Terasaki P. I. Evidence for immunosuppression by high-dose gammaglobulin. Exp Hematol. 1987 Feb;15(2):133–136. [PubMed] [Google Scholar]
  38. Kay H. D., Bonnard G. D., West W. H., Herberman R. B. A functional comparison of human Fc-receptor-bearing lymphocytes active in natural cytotoxicity and antibody-dependent cellular cytotoxicity. J Immunol. 1977 Jun;118(6):2058–2066. [PubMed] [Google Scholar]
  39. Khayat D., Geffrier C., Yoon S., Scigliano E., Soubrane C., Weil M., Unkeless J. C., Jacquillat C. Soluble circulating Fc gamma receptors in human serum. A new ELISA assay for specific and quantitative detection. J Immunol Methods. 1987 Jun 26;100(1-2):235–241. doi: 10.1016/0022-1759(87)90194-3. [DOI] [PubMed] [Google Scholar]
  40. Kimberly R. P., Salmon J. E., Bussel J. B., Crow M. K., Hilgartner M. W. Modulation of mononuclear phagocyte function by intravenous gamma-globulin. J Immunol. 1984 Feb;132(2):745–750. [PubMed] [Google Scholar]
  41. Kurata Y., Tsubakio T., Yonezawa T., Tarui S. High-dose gammaglobulin therapy for idiopathic thrombocytopenic purpura in adults. Acta Haematol. 1983;69(6):391–397. doi: 10.1159/000206927. [DOI] [PubMed] [Google Scholar]
  42. Kurlander R. J. Reversible and irreversible loss of Fc receptor function of human monocytes as a consequence of interaction with immunoglobulin G. J Clin Invest. 1980 Oct;66(4):773–781. doi: 10.1172/JCI109915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Latif Z. A., Fletcher M. A. Immunochemical studies of infectious mononucleosis--XI. comparison of heterophile antibody inhibitors from the erythrocyte membranes of four mammalian species. Mol Immunol. 1983 Jan;20(1):1–10. doi: 10.1016/0161-5890(83)90099-8. [DOI] [PubMed] [Google Scholar]
  44. Lucas G. S., Jobbins K., Bloom A. L. Intravenous immunoglobulin and blood group antibodies. Lancet. 1987 Sep 26;2(8561):742–742. doi: 10.1016/s0140-6736(87)91100-7. [DOI] [PubMed] [Google Scholar]
  45. Macey M. G., Sangster J. M., Newland A. C. Blood group and response to high dose IgG. Lancet. 1985 Jun 22;1(8443):1445–1445. doi: 10.1016/s0140-6736(85)91869-0. [DOI] [PubMed] [Google Scholar]
  46. Minchinton R. M., McGrath K. Binding and antibody blocking effects of intravenous IgG preparation on peripheral blood cells. Clin Lab Haematol. 1987;9(1):49–58. doi: 10.1111/j.1365-2257.1987.tb01381.x. [DOI] [PubMed] [Google Scholar]
  47. Morgenstern G. R., Measday B., Hegde U. M. Autoimmune thrombocytopenia in pregnancy: new approach to management. Br Med J (Clin Res Ed) 1983 Aug 27;287(6392):584–584. doi: 10.1136/bmj.287.6392.584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Newland A. C., Treleaven J. G., Minchinton R. M., Waters A. H. High-dose intravenous IgG in adults with autoimmune thrombocytopenia. Lancet. 1983 Jan 15;1(8316):84–87. doi: 10.1016/s0140-6736(83)91738-5. [DOI] [PubMed] [Google Scholar]
  49. Reiquam C. W., Prosper J. C. Fresh plasma transfusions in the treatment of acute thrombocytopenic purpura. J Pediatr. 1966 Jun;68(6):880–884. doi: 10.1016/s0022-3476(66)80205-6. [DOI] [PubMed] [Google Scholar]
  50. Rewald E. Repeated low doses of anti-rhesus gammaglobulin in aplastic anaemia. Lancet. 1987 Oct 3;2(8562):795–795. doi: 10.1016/s0140-6736(87)92522-0. [DOI] [PubMed] [Google Scholar]
  51. Riggio R. R., Cheigh J. S., Stenzel K. H., Suthanthiran M., Chami J., Saal S. D., Sullivan J. F., Haschemeyer R., Tapia L., Stubenbord W. T. Kidney transplantation; use of gamma globulin as an immunosuppressive agent. N Y State J Med. 1980 Sep;80(10):1561–1563. [PubMed] [Google Scholar]
  52. Roll J., Boyer J. L., Barry D., Klatskin G. The prognostic importance of clinical and histologic features in asymptomatic and symptomatic primary biliary cirrhosis. N Engl J Med. 1983 Jan 6;308(1):1–7. doi: 10.1056/NEJM198301063080101. [DOI] [PubMed] [Google Scholar]
  53. Römer J., Morgenthaler J. J., Scherz R., Skvaril F. Characterization of various immunoglobulin preparations for intravenous application. I. Protein composition and antibody content. Vox Sang. 1982 Feb;42(2):62–73. doi: 10.1159/000460850. [DOI] [PubMed] [Google Scholar]
  54. Salama A., Kiefel V., Amberg R., Mueller-Eckhardt C. Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies (anti-Rh0(D). Blut. 1984 Jul;49(1):29–35. doi: 10.1007/BF00320381. [DOI] [PubMed] [Google Scholar]
  55. Salama A., Mueller-Eckhardt C., Kiefel V. Effect of intravenous immunoglobulin in immune thrombocytopenia. Lancet. 1983 Jul 23;2(8343):193–195. doi: 10.1016/s0140-6736(83)90175-7. [DOI] [PubMed] [Google Scholar]
  56. Saleh M. N., Court W. S., LoBuglio A. F. In vitro effects of gammaglobulin (IgG) on human monocyte Fc receptor function. I. Effect on monocyte membrane-associated IgG and Fc receptor-dependent binding of antibody-coated platelets. Am J Hematol. 1986 Nov;23(3):197–207. doi: 10.1002/ajh.2830230303. [DOI] [PubMed] [Google Scholar]
  57. Salmon J. E., Kapur S., Kimberly R. P. Gammaglobulin for intravenous use induces an Fc gamma receptor-specific decrement in phagocytosis by blood monocytes. Clin Immunol Immunopathol. 1987 Apr;43(1):23–33. doi: 10.1016/0090-1229(87)90154-1. [DOI] [PubMed] [Google Scholar]
  58. Sandilands G. P., Atrah H. I., Templeton G., Cocker J. E., Lucie N., Crawford R. J., MacSween R. N. In vivo and in vitro blocking of human lymphocyte Fc gamma-receptors by intravenous gammaglobulin. J Clin Lab Immunol. 1987 Jul;23(3):109–115. [PubMed] [Google Scholar]
  59. Schmidt B., Forster J. Increased platelet-associated IgG in child on high-dose gammaglobulin for idiopathic thrombocytopenic purpura. Lancet. 1982 Jul 3;2(8288):39–40. doi: 10.1016/s0140-6736(82)91168-0. [DOI] [PubMed] [Google Scholar]
  60. Schmidt R. E., Budde U., Bröschen-Zywietz C., Schäfer G., Mueller-Eckhardt C. High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP). Clinical effects. Blut. 1984 Jan;48(1):19–25. doi: 10.1007/BF00320713. [DOI] [PubMed] [Google Scholar]
  61. Schmidt R. E., Budde U., Schäfer G., Stroehmann I. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura. Lancet. 1981 Aug 29;2(8244):475–476. doi: 10.1016/s0140-6736(81)90810-2. [DOI] [PubMed] [Google Scholar]
  62. Solal-Celigny P., Bernard J. F., Herrera A., Boivin P. Treatment of adult autoimmune thrombocytopenic purpura with high-dose intravenous plasmin-cleaved gammaglobulins. Scand J Haematol. 1983 Jul;31(1):39–44. doi: 10.1111/j.1600-0609.1983.tb02134.x. [DOI] [PubMed] [Google Scholar]
  63. Stiehm E. R., Ashida E., Kim K. S., Winston D. J., Haas A., Gale R. P. Intravenous immunoglobulins as therapeutic agents. Ann Intern Med. 1987 Sep;107(3):367–382. doi: 10.7326/0003-4819-107-2-367. [DOI] [PubMed] [Google Scholar]
  64. Stohl W. Cellular mechanisms in the in vitro inhibition of pokeweed mitogen-induced B cell differentiation by immunoglobulin for intravenous use. J Immunol. 1986 Jun 15;136(12):4407–4413. [PubMed] [Google Scholar]
  65. Sultan Y., Kazatchkine M. D., Maisonneuve P., Nydegger U. E. Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin. Lancet. 1984 Oct 6;2(8406):765–768. doi: 10.1016/s0140-6736(84)90701-3. [DOI] [PubMed] [Google Scholar]
  66. Thomas E. D., Storb R. Acquired severe aplastic anemia: progress and perplexity. Blood. 1984 Aug;64(2):325–328. [PubMed] [Google Scholar]
  67. Tovo P. A., Miniero R., Fiandino G., Saracco P., Messina M. Fc-depleted vs intact intravenous immunoglobulin in chronic ITP. J Pediatr. 1984 Oct;105(4):676–677. doi: 10.1016/s0022-3476(84)80455-2. [DOI] [PubMed] [Google Scholar]
  68. Tsubakio T., Kurata Y., Katagiri S., Kanakura Y., Tamaki T., Kuyama J., Kanayama Y., Yonezawa T., Tarui S. Alteration of T cell subsets and immunoglobulin synthesis in vitro during high dose gamma-globulin therapy in patients with idiopathic thrombocytopenic purpura. Clin Exp Immunol. 1983 Sep;53(3):697–702. [PMC free article] [PubMed] [Google Scholar]
  69. Uchida T., Yui T., Umezu H., Kariyone S. Prolongation of platelet survival in idiopathic thrombocytopenic purpura by high-dose intravenous gamma globulin. Thromb Haemost. 1984 Feb 28;51(1):65–66. [PubMed] [Google Scholar]
  70. Vaughn M., Taylor M., Mohanakumar T. Characterization of human IgG Fc receptors. J Immunol. 1985 Dec;135(6):4059–4065. [PubMed] [Google Scholar]
  71. Winiarski J., Kreuger A., Ejderhamn J., Holm G. High dose intravenous IgG reduces platelet associated immunoglobulins and complement in idiopathic thrombocytopenic purpura. Scand J Haematol. 1983 Oct;31(4):342–348. doi: 10.1111/j.1600-0609.1983.tb00662.x. [DOI] [PubMed] [Google Scholar]

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