Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1988 Dec;41(12):1316–1321. doi: 10.1136/jcp.41.12.1316

Campylobacter pylori: clinical, histological, and serological studies.

C Musgrove 1, F J Bolton 1, A M Krypczyk 1, J M Temperley 1, S A Cairns 1, W G Owen 1, D N Hutchinson 1
PMCID: PMC1141767  PMID: 3225334

Abstract

The presence of Campylobacter pylori, histologically diagnosed gastritis, and antibodies to C pylori were determined in a series of 113 patients undergoing endoscopy. Paired biopsy specimens from the fundus, body, and antrum were collected from 59 patients and from the antrum of 54 patients. The presence of C pylori was confirmed by either culture or silver stain in 30 of 59, 31 of 59, and 54 of 103 biopsy specimens from the fundus, body, and antrum, respectively. Of the specimens which contained C pylori 20 of 30 (66%) from the fundus, 25 of 31 (80%) from the body, and 54 (100%) from the antrum showed gastritis. C pylori and gastritis were shown in seven of nine (78.1%) of patients with gastric ulcers and in nine of 11 (82%) of patients with duodenal ulcers. Using an enzyme linked immunosorbent assay (ELISA) technique to detect IgG antibody to C pylori, all patients with histologically diagnosed gastritis and organisms present had titres of greater than or equal to 640; eight of 39 (21%) of patients without gastritis and without organisms gave similar titres. Hence the presence of C pylori was associated with gastritis and with raised titres of IgG antibody.

Full text

PDF
1317

Images in this article

1317Fig 1
on p.1317
1318Fig 2
on p.1318

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Booth L., Holdstock G., MacBride H., Hawtin P., Gibson J. R., Ireland A., Bamforth J., DuBoulay C. E., Lloyd R. S., Pearson A. D. Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy. J Clin Pathol. 1986 Feb;39(2):215–219. doi: 10.1136/jcp.39.2.215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dixon M. F., O'Connor H. J., Axon A. T., King R. F., Johnston D. Reflux gastritis: distinct histopathological entity? J Clin Pathol. 1986 May;39(5):524–530. doi: 10.1136/jcp.39.5.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gastric spiral bacteria. Lancet. 1984 Jul 14;2(8394):100–101. [PubMed] [Google Scholar]
  4. Gastric spiral bacteria. Lancet. 1984 Jul 14;2(8394):100–101. [PubMed] [Google Scholar]
  5. Goodwin C. S., Armstrong J. A., Marshall B. J. Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol. 1986 Apr;39(4):353–365. doi: 10.1136/jcp.39.4.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goodwin C. S., Blincow E. D., Warren J. R., Waters T. E., Sanderson C. R., Easton L. Evaluation of cultural techniques for isolating Campylobacter pyloridis from endoscopic biopsies of gastric mucosa. J Clin Pathol. 1985 Oct;38(10):1127–1131. doi: 10.1136/jcp.38.10.1127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jones D. M., Lessells A. M., Eldridge J. Campylobacter like organisms on the gastric mucosa: culture, histological, and serological studies. J Clin Pathol. 1984 Sep;37(9):1002–1006. doi: 10.1136/jcp.37.9.1002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kasper G., Dickgiesser N. Isolation from gastric epithelium of Campylobacter-like bacteria that are distinct from "Campylobacter pyloridis". Lancet. 1985 Jan 12;1(8420):111–112. doi: 10.1016/s0140-6736(85)92005-7. [DOI] [PubMed] [Google Scholar]
  9. Lambert J. R., Dunn K. L., Eaves E. R., Korman M. G., Hansky J., Pinkard K. J. Pyloric CLO in the human stomach. Med J Aust. 1985 Aug 19;143(4):174–174. doi: 10.5694/j.1326-5377.1985.tb122895.x. [DOI] [PubMed] [Google Scholar]
  10. Marshall B. J., Armstrong J. A., McGechie D. B., Glancy R. J. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust. 1985 Apr 15;142(8):436–439. doi: 10.5694/j.1326-5377.1985.tb113443.x. [DOI] [PubMed] [Google Scholar]
  11. Marshall B. J., McGechie D. B., Francis G. J., Utley P. J. Pyloric campylobacter serology. Lancet. 1984 Aug 4;2(8397):281–281. doi: 10.1016/s0140-6736(84)90318-0. [DOI] [PubMed] [Google Scholar]
  12. Marshall B. J., McGechie D. B., Rogers P. A., Glancy R. J. Pyloric Campylobacter infection and gastroduodenal disease. Med J Aust. 1985 Apr 15;142(8):439–444. doi: 10.5694/j.1326-5377.1985.tb113444.x. [DOI] [PubMed] [Google Scholar]
  13. O'Connor H. J., Wyatt J. I., Dixon M. F., Axon A. T. Campylobacter like organisms and reflux gastritis. J Clin Pathol. 1986 May;39(5):531–534. doi: 10.1136/jcp.39.5.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rathbone B. J., Wyatt J. I., Worsley B. W., Trejdosiewicz L. K., Heatley R. V., Losowsky M. S. Immune response to Campylobacter pyloridis. Lancet. 1985 May 25;1(8439):1217–1217. doi: 10.1016/s0140-6736(85)92897-1. [DOI] [PubMed] [Google Scholar]
  15. Rollason T. P., Stone J., Rhodes J. M. Spiral organisms in endoscopic biopsies of the human stomach. J Clin Pathol. 1984 Jan;37(1):23–26. doi: 10.1136/jcp.37.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983 Jun 4;1(8336):1273–1275. [PubMed] [Google Scholar]
  17. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983 Jun 4;1(8336):1273–1275. [PubMed] [Google Scholar]
  18. VIAL J. D., ORREGO H. Electron microscope observations on the fine structure of parietal cells. J Biophys Biochem Cytol. 1960 Apr;7:367–372. doi: 10.1083/jcb.7.2.367. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES