Abstract
A model for calculating the low-frequency modes in DNA molecules is presented. The present model is associated with the 'breathing' of a DNA molecule as well as its complementary hydrogen bonds. The calculated results show excellent agreement with the observed low-frequency wavenumber (30 cm-1). Consequently, such an internal motion as reflected in the proposed model might be the origin of the observed low-frequency vibration in DNA molecules. This is helpful for investigating the relevant biological functions, which so far have been discussed by many scientists.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown K. G., Erfurth S. C., Small E. W., Peticolas W. L. Conformationally dependent low-frequency motions of proteins by laser Raman spectroscopy. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1467–1469. doi: 10.1073/pnas.69.6.1467. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Careri G., Fasella P., Gratton E. Statistical time events in enzymes: a physical assessment. CRC Crit Rev Biochem. 1975 Aug;3(2):141–164. doi: 10.3109/10409237509102555. [DOI] [PubMed] [Google Scholar]
- Chou K. C. Identification of low-frequency modes in protein molecules. Biochem J. 1983 Dec 1;215(3):465–469. doi: 10.1042/bj2150465. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chou K. C. Low-frequency vibrations of helical structures in protein molecules. Biochem J. 1983 Mar 1;209(3):573–580. doi: 10.1042/bj2090573. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fanconi B., Small E. W., Peticolas W. L. Phonon dispersion curves and normal coordinate analysis of -poly-L-alanine. Biopolymers. 1971;10(8):1277–1298. doi: 10.1002/bip.360100804. [DOI] [PubMed] [Google Scholar]
- Genzel L., Keilmann F., Martin T. P., Winterling G., Yacoby Y., Fröhlich H., Makinen M. W. Low-frequency Raman spectra of lysozyme. Biopolymers. 1976 Jan;15(1):219–225. doi: 10.1002/bip.1976.360150115. [DOI] [PubMed] [Google Scholar]
- Ito K., Shimanouchi T. Vibrational frequencies and modes of alpha-helix. Biopolymers. 1970;9(4):383–399. doi: 10.1002/bip.1970.360090402. [DOI] [PubMed] [Google Scholar]
- Ji S. Energy and negentropy in enzymic catalysis. Ann N Y Acad Sci. 1974 Feb 18;227:419–437. doi: 10.1111/j.1749-6632.1974.tb14405.x. [DOI] [PubMed] [Google Scholar]
- Mandal C., Kallenbach N. R., Englander S. W. Base-pair opening and closing reactions in the double helix. A stopped-flow hydrogen exchange study in poly(rA).poly(rU). J Mol Biol. 1979 Dec 5;135(2):391–411. doi: 10.1016/0022-2836(79)90443-1. [DOI] [PubMed] [Google Scholar]
- Manning G. S. Breathing and bending fluctuations in DNA modeled by an open-base-pair kink coupled to axial compression. Biopolymers. 1983 Feb;22(2):689–729. doi: 10.1002/bip.360220211. [DOI] [PubMed] [Google Scholar]
- Painter P. C., Mosher L. E., Rhoads C. Low-frequency modes in the Raman spectra of proteins. Biopolymers. 1982 Jul;21(7):1469–1472. doi: 10.1002/bip.360210715. [DOI] [PubMed] [Google Scholar]
- Sobell H. M., Lozansky E. D., Lessen M. Structural and energetic considerations of wave propagation in DNA. Cold Spring Harb Symp Quant Biol. 1979;43(Pt 1):11–19. doi: 10.1101/sqb.1979.043.01.004. [DOI] [PubMed] [Google Scholar]
- Suezaki Y., Go N. Breathing mode of conformational fluctuations in globular proteins. Int J Pept Protein Res. 1975;7(4):333–334. doi: 10.1111/j.1399-3011.1975.tb02448.x. [DOI] [PubMed] [Google Scholar]