Abstract
Inhibition of rat intestinal retinyl ester hydrolase by alpha-tocopherol (vitamin E) and phylloquinone (vitamin K1) was non-competitive. Maximum inhibition occurred within 10 min, and, particularly with alpha-tocopherol, was substantially reversible. Consequently, increasing tissue concentrations of retinyl esters, which might occur with advancing age or changes in diet, would not diminish the effects of the inhibitors. These data further support the notion that alpha-tocopherol may, at physiological concentrations, influence the concentration of vitamin A and its ester in tissues.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Belfrage P., Vaughan M. Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res. 1969 May;10(3):341–344. [PubMed] [Google Scholar]
- MOORE T. The pathology of vitamin A deficiency. Vitam Horm. 1960;18:499–514. doi: 10.1016/s0083-6729(08)60877-8. [DOI] [PubMed] [Google Scholar]
- Moore T. The effect of vitamin E deficiency on the vitamin A reserves of the rat. Biochem J. 1940 Sep;34(8-9):1321–1328. doi: 10.1042/bj0341321. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Napoli J. L., McCormick A. M., O'Meara B., Dratz E. A. Vitamin A metabolism: alpha-tocopherol modulates tissue retinol levels in vivo, and retinyl palmitate hydrolysis in vitro. Arch Biochem Biophys. 1984 Apr;230(1):194–202. doi: 10.1016/0003-9861(84)90100-0. [DOI] [PubMed] [Google Scholar]
- Prystowsky J. H., Smith J. E., Goodman D. S. Retinyl palmitate hydrolase activity in normal rat liver. J Biol Chem. 1981 May 10;256(9):4498–4503. [PubMed] [Google Scholar]
- Ruggieri S., Roblin R., Black P. H. Lipids of whole cells and plasma membrane fractions from Balb/c3T3, SV3T3, and concanavalin A-selected revertant cells. J Lipid Res. 1979 Aug;20(6):760–771. [PubMed] [Google Scholar]
- Sondergaard E. The influence of vitamin E on the expenditure of vitamin A from the liver. Experientia. 1972 Jul 15;28(7):773–774. doi: 10.1007/BF01923121. [DOI] [PubMed] [Google Scholar]
- Sporn M. B. Retinoids and carcinogenesis. Nutr Rev. 1977 Apr;35(4):65–69. doi: 10.1111/j.1753-4887.1977.tb06541.x. [DOI] [PubMed] [Google Scholar]