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. 1985 Jul 1;229(1):101–108. doi: 10.1042/bj2290101

Experimentally induced defects of mitochondrial metabolism in rat skeletal muscle. Biological effects of the mitochondrial uncoupling agent 2,4-dinitrophenol.

E Byrne, D J Hayes, E A Shoubridge, J A Morgan-Hughes, J B Clark
PMCID: PMC1145155  PMID: 4038252

Abstract

Infusion of dinitrophenol intra-arterially into rat hind limb caused an irreversible failure of isometric twitch tension and the induction of a severe progressive contracture. Metabolite analysis of muscle in which the twitch response had grossly fatigued revealed low levels of ATP and phosphocreatine together with lactate accumulation. Studies using 31P-n.m.r. confirmed the decrease in ATP and creatine phosphate concentrations and indicated a fall in intracellular pH. It is concluded that dinitrophenol-induced myopathy does not represent a good model for the human mitochondrial myopathic condition as has been previously suggested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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