Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1979 Aug;32(8):826–831. doi: 10.1136/jcp.32.8.826

Anti-cartilage antibody.

C L Greenbury, J Skingle
PMCID: PMC1145817  PMID: 389957

Abstract

Antibody to cartilage has been demonstrated by indirect immunofluorescence on rat trachea in the serum of about 3% of 1126 patients with rheumatoid arthritis. Titres ranged from 1:20 to 1:640. The antibody was not found in 284 patients with primary or secondary osteoarthritis or in 1825 blood donors, nor, with the exception of two weak reactors, in 1314 paraplegic patients. In most cases the antibody appears to be specific for native type II collagen. Using this as an antigen in a haemagglutination test 94% of anti-cartilage sera were positive, whereas among 100 rheumatoid control sera there were only three weak positives. More than 80% of patients with antibody had some erosion of articular cartilage, but there was no correlation with age, sex, duration of disease, nor any recognisable clinical event or change.

Full text

PDF
829

Images in this article

827Fig. 1
on p.827

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adam M., Bozdech V., Musilová J., Deyl Z. Rheumatoid arthritis and collagen antibodies. Scand J Rheumatol. 1977;6(3):186–188. doi: 10.3109/03009747709095447. [DOI] [PubMed] [Google Scholar]
  2. Andriopoulos N. A., Mestecky J., Miller E. J., Bennett J. C. Antibodies to human native and denatured collagens in synovial fluids of patients with rheumatoid arthritis. Clin Immunol Immunopathol. 1976 Sep;6(2):209–212. doi: 10.1016/0090-1229(76)90112-4. [DOI] [PubMed] [Google Scholar]
  3. Andriopoulos N. A., Mestecky J., Miller E. J., Bradley E. L. Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis. Arthritis Rheum. 1976 May-Jun;19(3):613–617. doi: 10.1002/art.1780190314. [DOI] [PubMed] [Google Scholar]
  4. Andriopoulos N. A., Mestecky J., Wright G. P., Miller E. J. Characterization of antibodies to the native human collagens and to their component alpha chains in the sera and the joint fluids of patients with rheumatoid arthritis. Immunochemistry. 1976 Aug;13(8):709–712. doi: 10.1016/0019-2791(76)90213-5. [DOI] [PubMed] [Google Scholar]
  5. Cracchiolo A., 3rd, Michaeli D., Goldberg L. S., Fudenberg H. H. The occurrence of antibodies to collagen in synovial fluids. Clin Immunol Immunopathol. 1975 Mar;3(4):567–574. doi: 10.1016/0090-1229(75)90081-1. [DOI] [PubMed] [Google Scholar]
  6. Eyre D. R., Muir H. The distribution of different molecular species of collagen in fibrous, elastic and hyaline cartilages of the pig. Biochem J. 1975 Dec;151(3):595–602. doi: 10.1042/bj1510595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Eyre D. R., Muir H. Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus. Biochem J. 1976 Jul 1;157(1):267–270. doi: 10.1042/bj1570267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Greenbury C. L., Keningale J. A COMPARISON OF THE ROSE-WAALER, LATEX FIXATION, "RA-TEST," AND BENTONITE FLOCCULATION TESTS. J Clin Pathol. 1960 Jul;13(4):325–330. doi: 10.1136/jcp.13.4.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hughes R. A., Berry C. L., Seifert M., Lessof M. H. Relapsing polychondritis. Three cases with a clinico-pathological study and literature review. Q J Med. 1972 Jul;41(163):363–380. [PubMed] [Google Scholar]
  10. Menzel J., Steffen C., Kolarz G., Eberal G., Frank O., Thumb N. Demonstration of antibodies to collagen and of collagen-anticollagen immune complexes in rheumatoid arthritis synovial fluids. Ann Rheum Dis. 1975 Oct;35(5):446–450. doi: 10.1136/ard.35.5.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mestecky J., Miller E. J. Presence of antibodies specific to cartilage-type collagen in rheumatoid synovial tissue. Clin Exp Immunol. 1975 Dec;22(3):453–456. [PMC free article] [PubMed] [Google Scholar]
  12. Michaeli D., Fudenberg H. H. The incidence and antigenic specificity of antibodies against denatured human collagen in rheumatoid arthritis. Clin Immunol Immunopathol. 1974 Jan;2(2):153–159. doi: 10.1016/0090-1229(74)90035-x. [DOI] [PubMed] [Google Scholar]
  13. Miller E. J. A review of biochemical studies on the genetically distinct collagens of the skeletal system. Clin Orthop Relat Res. 1973 May;(92):260–280. doi: 10.1097/00003086-197305000-00024. [DOI] [PubMed] [Google Scholar]
  14. Rogers P. H., Boden G., Tourtellotte C. D. Relapsing polychondritis with insulin resistance and antibodies to cartilage. Am J Med. 1973 Aug;55(2):243–248. doi: 10.1016/0002-9343(73)90175-7. [DOI] [PubMed] [Google Scholar]
  15. Steffen C. Consideration of pathogenesis of rheumatoid arthritis as collagen autoimmunity. Z Immunitatsforsch Allerg Klin Immunol. 1970 Apr;139(3):219–227. [PubMed] [Google Scholar]
  16. Trentham D. E., Townes A. S., Kang A. H. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977 Sep 1;146(3):857–868. doi: 10.1084/jem.146.3.857. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES