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. 1980 Sep;33(9):801–810. doi: 10.1136/jcp.33.9.801

Role of intestinal metaplasia in the histogenesis of gastric carcinoma.

J R Jass
PMCID: PMC1146235  PMID: 7430392

Abstract

Recent evidence suggests that intestinal metaplasia (IM) cannot be regarded as a single entity. A simple classification of IM and its variants based on histological and mucin histochemical criteria was devised, and the incidence of IM subtypes in cancerous and benign gastrectomy specimens was recorded. A particular subtype was associated with 'intestinal' cancers but not with tumours considered to arise in normal gastric epithelium (P < 0.01) or with benign lesions (P < 0.01). This subtype appeared to lack absorptive cells at light microscopic level and secreted both neutral and acid mucins, including marked amounts of sulphomucin but no O-acetyl sialomucin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burtin P., von Kleist S., Sabine M. C., King M. Immunohistological localization of carcinoembryonic antigen and nonspecific cross-reacting antigen in gastrointestinal normal and tumoral tissues. Cancer Res. 1973 Dec;33(12):3299–3305. [PubMed] [Google Scholar]
  2. Culling C. F., Reid P. E., Clay M. G., Dunn W. L. The histochemical demonstration of O-acylated sialic acid in gastrointestinal mucins. Their association with the potassium hydroxide-periodic acid-schiff effect. J Histochem Cytochem. 1974 Aug;22(8):826–831. doi: 10.1177/22.8.826. [DOI] [PubMed] [Google Scholar]
  3. Filipe M. I. Mucins in the human gastrointestinal epithelium: a review. Invest Cell Pathol. 1979 Jul-Sep;2(3):195–216. [PubMed] [Google Scholar]
  4. Filipe M. I. Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study. Br J Cancer. 1975 Jul;32(1):60–77. doi: 10.1038/bjc.1975.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Goldman H., Ming S. C. Fine structure of intestinal metaplasia and adenocarcinoma of the human stomach. Lab Invest. 1968 Feb;18(2):203–210. [PubMed] [Google Scholar]
  6. Goldman H., Ming S. C. Mucins in normal and neoplastic gastrointestinal epithelium. Histochemical distribution. Arch Pathol. 1968 Jun;85(6):580–586. [PubMed] [Google Scholar]
  7. Heilmann K. L., Höpker W. W. Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphologic study. Pathol Res Pract. 1979 Jan;164(3):249–258. doi: 10.1016/S0344-0338(79)80047-3. [DOI] [PubMed] [Google Scholar]
  8. Häkkinen I., Järvi O., Grönroos J. Sulphoglycoprotein antigens in the human alimentary canal and gastric cancer. An immunohistological study. Int J Cancer. 1968 Sep 15;3(5):572–581. doi: 10.1002/ijc.2910030506. [DOI] [PubMed] [Google Scholar]
  9. Iida F., Murata F., Nagata T. Histochemical studies of mucosubstances in metaplastic epithelium of the stomach, with special reference to the development of intestinal metaplasia. Histochemistry. 1978 Jul 12;56(3-4):229–237. doi: 10.1007/BF00495984. [DOI] [PubMed] [Google Scholar]
  10. Imai T., Kubo T., Watanabe H. Chronic gastritis in Japanese with reference to high incidence of gastric carcinoma. J Natl Cancer Inst. 1971 Jul;47(1):179–195. [PubMed] [Google Scholar]
  11. Jass J. R., Filipe M. I. A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study. Histopathology. 1979 May;3(3):191–199. doi: 10.1111/j.1365-2559.1979.tb02996.x. [DOI] [PubMed] [Google Scholar]
  12. Kawachi T., Kurisu M., Numanyu N., Sasajima K., Sano T. Precancerous changes in the stomach. Cancer Res. 1976 Jul;36(7 Pt 2):2673–2677. [PubMed] [Google Scholar]
  13. Kobori O., Oota K. Mucous substance and enzyme histochemistry of non-neoplastic and neoplastic gastric epithelium in man. Acta Pathol Jpn. 1974 Jan;24(1):119–130. doi: 10.1111/j.1440-1827.1974.tb00811.x. [DOI] [PubMed] [Google Scholar]
  14. LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. doi: 10.1111/apm.1965.64.1.31. [DOI] [PubMed] [Google Scholar]
  15. Lev R. The mucin histochemistry of normal and neoplastic gastric mucosa. Lab Invest. 1965 Dec;14(12):2080–2100. [PubMed] [Google Scholar]
  16. MORSON B. C. Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa. Br J Cancer. 1955 Sep;9(3):377–385. doi: 10.1038/bjc.1955.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. MORSON B. C. Intestinal metaplasia of the gastric mucosa. Br J Cancer. 1955 Sep;9(3):365–376. doi: 10.1038/bjc.1955.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Ming S. C. Gastric carcinoma. A pathobiological classification. Cancer. 1977 Jun;39(6):2475–2485. doi: 10.1002/1097-0142(197706)39:6<2475::aid-cncr2820390626>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  19. Ming S. C., Goldman H., Freiman D. G. Intestinal metaplasia and histogenesis of carcinoma in human stomach. Light and electron microscopic study. Cancer. 1967 Sep;20(9):1418–1429. doi: 10.1002/1097-0142(196709)20:9<1418::aid-cncr2820200908>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  20. Mori T., Wakumoto H., Shimano T., Lee P. K., Higashi H. Immunopathological studies on CEA and CEA-associated antigens with reevaluation of the cancer specificities of CEA. Ann N Y Acad Sci. 1975 Aug 22;259:412–416. doi: 10.1111/j.1749-6632.1975.tb25438.x. [DOI] [PubMed] [Google Scholar]
  21. Nakamura K., Sugano H., Takagi K. Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gan. 1968 Jun;59(3):251–258. [PubMed] [Google Scholar]
  22. OFSTAD J. The effect of hydrochlorothiazide on patients with oedema. Acta Med Scand. 1960 May 5;166:445–453. doi: 10.1111/j.0954-6820.1960.tb17400.x. [DOI] [PubMed] [Google Scholar]
  23. PLANTEYDT H. T., WILLIGHAGEN R. G. Enzyme histochemistry of the human stomach, with spcial reference to intestinal metaplasia. J Pathol Bacteriol. 1960 Oct;80:317–323. doi: 10.1002/path.1700800215. [DOI] [PubMed] [Google Scholar]
  24. Rapp W., Windisch M., Peschke P., Wurster K. Purification of human intestinal goblet cell antigen (GOA), its immunohistological demonstration in the intestine and in mucus producing gastrointestinal adenocarcinomas. Virchows Arch A Pathol Anat Histol. 1979 May 31;382(2):163–177. doi: 10.1007/BF01102872. [DOI] [PubMed] [Google Scholar]
  25. Rubin W., Ross L. L., Jeffries G. H., Sleisenger M. H. Intestinal heterotopia. A fine structural study. Lab Invest. 1966 Jun;15(6):1024–1049. [PubMed] [Google Scholar]
  26. SPICER S. S. DIAMINE METHODS FOR DIFFERENTIALING MUCOSUBSTANCES HISTOCHEMICALLY. J Histochem Cytochem. 1965 Mar;13:211–234. doi: 10.1177/13.3.211. [DOI] [PubMed] [Google Scholar]
  27. Skinner J. M., Heenan P. J., Whitehead R. Atrophic gastritis in gastrectomy specimens. Br J Surg. 1975 Jan;62(1):23–25. doi: 10.1002/bjs.1800620107. [DOI] [PubMed] [Google Scholar]
  28. Stemmermann G. N. Comparative study of histochemical patterns in non-neoplastic and neoplastic gastric epithelium: a study of Japanese in Hawaii. J Natl Cancer Inst. 1967 Sep;39(3):375–383. [PubMed] [Google Scholar]
  29. Tarpila S., Telkkä A., Siurala M. Ultrastructure of various metaplasias of the stomach. Acta Pathol Microbiol Scand. 1969;77(2):187–195. doi: 10.1111/j.1699-0463.1969.tb04223.x. [DOI] [PubMed] [Google Scholar]
  30. Teglbjaerg P. S., Nielsen H. O. "Small intestinal type" and "colonic type" intestinal metaplasia of the human stomach, and their relationship to the histogenetic types of gastric adenocarcinoma. Acta Pathol Microbiol Scand A. 1978 Sep;86A(5):351–355. doi: 10.1111/j.1699-0463.1978.tb02055.x. [DOI] [PubMed] [Google Scholar]
  31. Thurnherr N., Deschner E. E., Stonehill E. H., Lipkin M. Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine. Cancer Res. 1973 May;33(5):940–945. [PubMed] [Google Scholar]
  32. WATTENBERG L. W. Histochemical study of aminopeptidase in metaplasia and carcinoma of the stomach. AMA Arch Pathol. 1959 Mar;67(3):281–286. [PubMed] [Google Scholar]
  33. Wiebecke B., Krey U., Löhrs U., Eder M. Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch A Pathol Pathol Anat. 1973 Sep 4;360(3):179–193. doi: 10.1007/BF00542979. [DOI] [PubMed] [Google Scholar]

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