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. 1986 Jun 15;236(3):917–919. doi: 10.1042/bj2360917

Hysteretic behaviour of carnitine palmitoyltransferase. The effect of preincubation with malonyl-CoA.

G A Cook, K A Cox
PMCID: PMC1146927  PMID: 3790097

Abstract

Continuous assays of carnitine palmitoyltransferase were used to study the hysteretic behaviour of the enzyme. When reactions were started by adding mitochondria to complete reaction mixtures, there was a lag in the assay even in the absence of malonyl-CoA. When mitochondria were preincubated with malonyl-CoA in the absence of palmitoyl-CoA, there was a greater lag period in the assay of carnitine palmitoyltransferase, but this lag was less prominent at 37 degrees C than at 30 degrees C. Preincubation of mitochondria with malonyl-CoA did not change the sensitivity of the enzyme to inhibition by malonyl-CoA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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