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. 1987 Jun 15;244(3):797–800. doi: 10.1042/bj2440797

The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin.

S J Dunmore 1, M Panico 1, A T Etienne 1, H R Morris 1, A Beloff-Chain 1
PMCID: PMC1148067  PMID: 2833221

Abstract

The minimal effective concentration of the pituitary insulin secretagogue beta-cell-tropin (beta-CT) on the in vitro perfused pancreas was established and the effects of various modifications of the peptide on its potency were tested: iodination with 127I and acetylation reduced the insulin-releasing activity of beta-cell-tropin, and the C-terminal fragments beta-CT-(2-18), beta-CT-(3-18) and beta-CT-(6-18) were all less potent than the intact molecule; beta-CT-(1-6) was not active and did not inhibit beta-CT-induced insulin release.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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