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. 1987 Sep 1;246(2):331–336. doi: 10.1042/bj2460331

Homologous beta-adrenergic desensitization in isolated rat hepatocytes.

J A García-Sáinz 1, B Michel 1
PMCID: PMC1148281  PMID: 2825633

Abstract

Hepatocytes from hypothyroid rats have a marked beta-adrenergic responsiveness. Preincubation of these hepatocytes with isoprenaline induced a time-dependent and concentration-dependent desensitization of the beta-adrenergic responsiveness without altering that to glucagon (homologous desensitization). The desensitization was evidenced both in the cyclic AMP accumulation and in the stimulation of ureagenesis induced by the beta-adrenergic agonists. Under the same conditions, preincubation with glucagon induced no desensitization. Propranolol was also unable to induce desensitization, but blocked that induced by isoprenaline. Pertussis-toxin treatment did not alter the homologous beta-adrenergic desensitization induced by isoprenaline.

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Selected References

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