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. 1988 Jan 15;249(2):443–449. doi: 10.1042/bj2490443

Amino acid metabolism in tumour-bearing mice.

S Rivera 1, J Azcón-Bieto 1, F J López-Soriano 1, M Miralpeix 1, J M Argilés 1
PMCID: PMC1148723  PMID: 3342022

Abstract

Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino acid degradation, glutamine being its preferred substrate.

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Selected References

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