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. 1988 Feb 15;250(1):247–252. doi: 10.1042/bj2500247

Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour.

K H Cheeseman 1, S Emery 1, S P Maddix 1, T F Slater 1, G W Burton 1, K U Ingold 1
PMCID: PMC1148840  PMID: 3128276

Abstract

Reduced rates of lipid peroxidation have been observed in Yoshida hepatoma cells and microsomes when compared with appropriate control tissue (normal rat liver) under the same pro-oxidant conditions. The pro-oxidant conditions used were incubation with NADPH+ADP+iron or ascorbate+iron or exposure to gamma-irradiation. As previously shown with the Novikoff hepatoma, the relative concentrations of alpha-tocopherol and polyunsaturated fatty acids are important in conferring resistance to lipid peroxidation in the Yoshida hepatoma. Furthermore, NADPH-cytochrome c reductase and the NADPH-cytochrome P-450 electron transport chain, which are involved in the initiation and propagation of certain types of lipid peroxidation, are found at very much reduced levels in the Yoshida hepatoma. The relative importance of these aberrations are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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