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. 1990 Oct 15;271(2):555–558. doi: 10.1042/bj2710555

Atrial natriuretic factor mRNA and binding sites in the adrenal gland.

D J Nunez 1, A P Davenport 1, M J Brown 1
PMCID: PMC1149591  PMID: 2146954

Abstract

The factor inhibiting aldosterone secretion produced by the adrenal medulla may be atrial natriuretic factor (ANF), since the latter abolishes aldosterone release in response to a number of secretagogues, including angiotensin II and K+. In this study we have shown that cells in the adrenal medulla contain ANF mRNA and therefore have the potential to synthesize this peptide. The presence of binding sites for ANF predominantly in the adrenal zona glomerulosa suggests that, if ANF is synthesized in the medulla and transferred to the cortex, it may affect mineralocorticoid status.

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Selected References

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