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. 1990 Nov 15;272(1):255–257. doi: 10.1042/bj2720255

Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles.

F Takao 1, M C Laury 1, A Ktorza 1, L Picon 1, L Pénicaud 1
PMCID: PMC1149686  PMID: 2264831

Abstract

The effect of 4 days of stable hyperglycaemia and resulting hyperinsulinaemia on insulin-induced glucose utilization by individual rat tissues was studied in vivo. The treatment produced a net increase in the glucose utilization index under both basal and insulin-stimulated (euglycaemic/hyperinsulinaemic clamp) conditions in white adipose tissue. On the contrary, glucose utilization was unchanged in aerobic muscles but was decreased in glycolytic skeletal muscles during the clamp.

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Selected References

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