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. 1991 May 15;276(Pt 1):109–111. doi: 10.1042/bj2760109

Inhibition of myoblast differentiation by lack of zinc.

L Petrie 1, J K Chesters 1, M Franklin 1
PMCID: PMC1151150  PMID: 2039464

Abstract

The impact of restricted zinc availability on myoblast differentiation was investigated. Lack of zinc prevented myoblast fusion and the increase in muscle-specific creatine kinase activity. The depression of activity of creatine kinase in the zinc-deficient cultures was accompanied by a similar decrease in the concentration of creatine kinase mRNA and was apparent even when fusion of the myoblasts was inhibited by cytochalasin B. Thus zinc appears to be necessary for the expression of creatine kinase during myoblast differentiation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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