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. 1991 May 15;276(Pt 1):183–187. doi: 10.1042/bj2760183

Expression of type X collagen is transiently stimulated in redifferentiating chondrocytes pretreated with retinoic acid.

M Sanchez 1, E Gionti 1, G Pontarelli 1, A Arcella 1, F De Lorenzo 1
PMCID: PMC1151162  PMID: 2039468

Abstract

Growth of quail chondrocytes in the presence of retinoic acid (RA) results in the suppression of the differentiated phenotype. RA-treated chondrocytes recover their differentiated phenotype if they are cultured for an additional 15 days in the absence of RA. A few days after removal from RA, treated chondrocytes acquire the polygonal morphology characteristic of chondrocytes growing as attached cells; they also gradually resume collagen II expression and synthesize cultures. The levels of collagen X mRNA decrease during the second week of culture in the absence of RA. Finally, at the end of 15 days, the absolute levels of collagen II and collagen X mRNAs are very similar in control and recovering chondrocytes.

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Selected References

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