Abstract
Metabolic acidosis stimulates the rate of glutamine release from muscle, and this in turn is used by the kidney in acid-base balance. NH4Cl, HCl or diabetic ketoacidosis increases the maximum activity of glutamine synthetase in skeletal muscle. Starvation and administration of adrenal steroids also increase the activity of the enzyme in muscle.
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Selected References
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- Blackshear P. J., Alberti K. G. Experimental diabetic ketoacidosis. Sequential changes of metabolic intermediates in blood, liver, cerebrospinal fluid and brain after acute insulin deprivation in the streptozotocin-diabetic rat. Biochem J. 1974 Jan;138(1):107–117. doi: 10.1042/bj1380107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Felig P. Amino acid metabolism in man. Annu Rev Biochem. 1975;44:933–955. doi: 10.1146/annurev.bi.44.070175.004441. [DOI] [PubMed] [Google Scholar]
- Felig P., Marliss E., Ohman J. L., Cahill C. F., Jr Plasma amino acid levels in diabetic ketoacidosis. Diabetes. 1970 Oct;19(10):727–728. doi: 10.2337/diab.19.10.727. [DOI] [PubMed] [Google Scholar]
- Goldstein L., Perlman D. F., McLaughlin P. M., King P. A., Cha C. J. Muscle glutamine production in diabetic ketoacidotic rats. Biochem J. 1983 Sep 15;214(3):757–767. doi: 10.1042/bj2140757. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harmon J. M., Thompson E. B. Glutamine synthetase induction by glucocorticoids in the glucocorticoid-sensitive human leukemic cell line CEM-C7. J Cell Physiol. 1982 Feb;110(2):155–160. doi: 10.1002/jcp.1041100208. [DOI] [PubMed] [Google Scholar]
- Iqbal K., Ottaway J. H. Glutamine synthetase in muscle and kidney. Biochem J. 1970 Sep;119(2):145–156. doi: 10.1042/bj1190145. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lund P. A radiochemical assay for glutamine synthetase, and activity of the enzyme in rat tissues. Biochem J. 1970 Jun;118(1):35–39. doi: 10.1042/bj1180035. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schröck H., Cha C. J., Goldstein L. Glutamine release from hindlimb and uptake by kidney in the acutely acidotic rat. Biochem J. 1980 May 15;188(2):557–560. doi: 10.1042/bj1880557. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schröck H., Goldstein L. Interorgan relationships for glutamine metabolism in normal and acidotic rats. Am J Physiol. 1981 May;240(5):E519–E525. doi: 10.1152/ajpendo.1981.240.5.E519. [DOI] [PubMed] [Google Scholar]
- Tiemeier D. C., Milman G. Chinese hamster liver glutamine synthetase. Purification, physical and biochemical properties. J Biol Chem. 1972 Apr 25;247(8):2272–2277. [PubMed] [Google Scholar]