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. 1986 Feb 1;233(3):899–904. doi: 10.1042/bj2330899

Structural analysis of the major urinary oligosaccharides in feline alpha-mannosidosis.

D Abraham, P Daniel, A Dell, J Oates, R Sidebotham, B Winchester
PMCID: PMC1153114  PMID: 3707532

Abstract

Two homologous series of urinary oligosaccharides were identified by h.p.l.c. and fast-atom-bombardment mass spectrometry in feline alpha-mannosidosis. The predominant series has the composition Man2-8GlcNAc2 and a minor series the composition Man2-9GlcNAc. The structure of the most abundant oligosaccharide, which accounts for over 80% of the urinary oligosaccharide, was shown to be alpha-D-Manp(1----3)[alpha-D-Manp-(1----6)]beta-D-Manp -(1----4)-beta-D-GlcpNA c-(1----4)-D-GlcNAc by gas chromatography and mass spectrometry. Such a structure is consistent with the incomplete catabolism of complex N-linked glycans due to a deficiency of alpha-D-mannosidase in tissue lacking an endohexosaminidase activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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