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. 1984 Mar 15;218(3):987–990. doi: 10.1042/bj2180987

Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.

M J Wilson, N Shivapurkar, L A Poirier
PMCID: PMC1153433  PMID: 6721844

Abstract

A progressive decrease was observed in the 5-methyldeoxycytidine content of hepatic DNA in male F344 rats fed with a hepatocarcinogenic methyl-deficient diet. The same dietary regimen resulted in altered hepatic contents of S-adenosylmethionine, the methyl-donating species, and S-adenosylhomocysteine, an inhibitor of DNA methylase. The data indicate that this carcinogenic dietary manipulation is sufficient to alter a possible regulatory process, DNA methylation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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