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. 1995 Oct 15;488(Pt 2):509–514. doi: 10.1113/jphysiol.1995.sp020985

Atrial natriuretic factor release during pregnancy in rats.

Y Zhang 1, K Novak 1, S Kaufman 1
PMCID: PMC1156689  PMID: 8568689

Abstract

1. We investigated the control of atrial natriuretic factor (ANF) secretion during pregnancy. 2. Plasma ANF levels were measured in conscious virgin female rats under basal conditions, and after atrial distension with an indwelling balloon catheter. The rats were then mated, and the measurements repeated at 7, 14 and 21 days of pregnancy, and at 1 week postpartum. Plasma ANF levels were also measured in ovariectomized rats injected with progesterone, oestradiol, or oestradiol plus progesterone. 3. Basal plasma ANF levels were elevated at 7 and 14 days of pregnancy, but returned to prepregnant levels by 21 days. At 1 week postpartum, they were again elevated. 4. In response to atrial stretch, plasma ANF increased significantly in virgin rats (from 100 +/- 10 to 148 +/- 13 pg ml-1, P < 0.001, n = 20). In contrast, there was no such secretory response observed in the pregnant and postpartum animals i.e. stretch-induced secretion of ANF was markedly attenuated. 5. Treatment with exogenous oestradiol caused a significant increase in plasma ANF levels in acyclic rats. However, neither progesterone nor a combination of oestradiol plus progesterone had any effect. 6. It is concluded that basal and stretch-induced ANF secretion are differentially influenced by pregnancy; oestradiol is identified as a potential stimulatory factor.

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Selected References

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  1. Barron W. M., Schreiber J., Lindheimer M. D. Effect of ovarian sex steroids on osmoregulation and vasopressin secretion in the rat. Am J Physiol. 1986 Apr;250(4 Pt 1):E352–E361. doi: 10.1152/ajpendo.1986.250.4.E352. [DOI] [PubMed] [Google Scholar]
  2. Barron W. M. Volume homeostasis during pregnancy in the rat. Am J Kidney Dis. 1987 Apr;9(4):296–302. doi: 10.1016/s0272-6386(87)80125-7. [DOI] [PubMed] [Google Scholar]
  3. Castro L. C., Arora C. P., Krakow D. E., Allen R. Atrial natriuretic peptide metabolism during pregnancy in the rat. Am J Obstet Gynecol. 1994 Apr;170(4):1184–1188. doi: 10.1016/s0002-9378(94)70119-9. [DOI] [PubMed] [Google Scholar]
  4. Castro L. C., Arora C., Parvez S., Parvez H., Valenzuela G., Hobel C. J. Plasma atrial natriuretic peptide levels during the rat estrous cycle, pregnancy, and puerperium. Am J Obstet Gynecol. 1989 Jan;160(1):15–19. doi: 10.1016/0002-9378(89)90078-1. [DOI] [PubMed] [Google Scholar]
  5. Deng Y., Kaufman S. The influence of reproductive hormones on ANF release by rat atria. Life Sci. 1993;53(9):689–696. doi: 10.1016/0024-3205(93)90245-x. [DOI] [PubMed] [Google Scholar]
  6. Fournier A., Gregoire I., el Esper N., Lalau J. D., Westeel P. F., Makdassi R., Fievet P., de Bold A. J. Atrial natriuretic factor in pregnancy and pregnancy-induced hypertension. Can J Physiol Pharmacol. 1991 Oct;69(10):1601–1608. doi: 10.1139/y91-237. [DOI] [PubMed] [Google Scholar]
  7. Gall J. A., Alcorn D., Fernley R., Coghlan J. P., Ryan G. B. Qualitative and quantitative analysis of granules in atrial appendage cardiocytes in different physiological states. Cell Tissue Res. 1990 Mar;259(3):529–534. doi: 10.1007/BF01740780. [DOI] [PubMed] [Google Scholar]
  8. Goetz K. L. Physiology and pathophysiology of atrial peptides. Am J Physiol. 1988 Jan;254(1 Pt 1):E1–15. doi: 10.1152/ajpendo.1988.254.1.E1. [DOI] [PubMed] [Google Scholar]
  9. Gregoire I., el Esper N., Gondry J., Boitte F., Fievet P., Makdassi R., Westeel P. F., Lalau J. D., Favre H., de Bold A. Plasma atrial natriuretic factor and urinary excretion of a ouabain displacing factor and dopamine in normotensive pregnant women before and after delivery. Am J Obstet Gynecol. 1990 Jan;162(1):71–76. doi: 10.1016/0002-9378(90)90823-p. [DOI] [PubMed] [Google Scholar]
  10. Hatjis C. G., Kofinas A. D., Greelish J. P., Swain M., Rose J. C. Interrelationship between atrial natriuretic factor concentrations and acute volume expansion in pregnant and nonpregnant women. Am J Obstet Gynecol. 1990 Jul;163(1 Pt 1):45–50. doi: 10.1016/s0002-9378(11)90664-4. [DOI] [PubMed] [Google Scholar]
  11. Heesch C. M., Rogers R. C. Effects of pregnancy and progesterone metabolites on regulation of sympathetic outflow. Clin Exp Pharmacol Physiol. 1995 Feb;22(2):136–142. doi: 10.1111/j.1440-1681.1995.tb01970.x. [DOI] [PubMed] [Google Scholar]
  12. Hirai N., Yanaihara T., Nakayama T., Ishibashi M., Yamaji T. Plasma levels of atrial natriuretic peptide during normal pregnancy and in pregnancy complicated by hypertension. Am J Obstet Gynecol. 1988 Jul;159(1):27–31. doi: 10.1016/0002-9378(88)90488-7. [DOI] [PubMed] [Google Scholar]
  13. Hong M., Yan Q., Tao B., Boersma A., Han K. K., Vantyghem M. C., Racadot A., Lefebvre J. Estradiol, progesterone and testosterone exposures affect the atrial natriuretic peptide gene expression in vivo in rats. Biol Chem Hoppe Seyler. 1992 Apr;373(4):213–218. doi: 10.1515/bchm3.1992.373.1.213. [DOI] [PubMed] [Google Scholar]
  14. Jansakul C., King R. G., Boura A. L., Brennecke S. P., Handberg G. M. Plasma levels of atrial natriuretic peptides during pregnancy and post partum in the rat. J Endocrinol. 1989 Jan;120(1):113–117. doi: 10.1677/joe.0.1200113. [DOI] [PubMed] [Google Scholar]
  15. Kaufman S., Deng Y. Renal response to atrial stretch during pregnancy in conscious rats. Am J Physiol. 1993 Oct;265(4 Pt 2):R902–R906. doi: 10.1152/ajpregu.1993.265.4.R902. [DOI] [PubMed] [Google Scholar]
  16. Kaufman S., Deng Y., Thai W. Influence of pregnancy on ANF release from isolated atria. Am J Physiol. 1994 May;266(5 Pt 2):R1605–R1609. doi: 10.1152/ajpregu.1994.266.5.R1605. [DOI] [PubMed] [Google Scholar]
  17. Kaufman S. Renal and hormonal responses to prolonged atrial stretch. Am J Physiol. 1990 May;258(5 Pt 2):R1286–R1290. doi: 10.1152/ajpregu.1990.258.5.R1286. [DOI] [PubMed] [Google Scholar]
  18. Kaufman S. Role of right atrial receptors in the control of drinking in the rat. J Physiol. 1984 Apr;349:389–396. doi: 10.1113/jphysiol.1984.sp015162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lang R. E., Unger T., Ganten D. Atrial natriuretic peptide: a new factor in blood pressure control. J Hypertens. 1987 Jun;5(3):255–271. doi: 10.1097/00004872-198706000-00001. [DOI] [PubMed] [Google Scholar]
  20. Lowe S. A., Macdonald G. J., Brown M. A. Regulation of atrial natriuretic peptide release in pregnancy: responses to posture. Am J Obstet Gynecol. 1991 Sep;165(3):591–595. doi: 10.1016/0002-9378(91)90291-x. [DOI] [PubMed] [Google Scholar]
  21. Marlettini M. G., Cassani A., Boschi S., Morselli Labate A. M., Crippa S., Borghi C., Contarini A., Rusticali A. G., Orlandi C. Plasma concentrations of atrial natriuretic factor in normal pregnancy and early puerperium. Clin Exp Hypertens A. 1989;11(4):531–552. doi: 10.3109/10641968909035359. [DOI] [PubMed] [Google Scholar]
  22. Nadel A. S., Ballermann B. J., Anderson S., Brenner B. M. Interrelationships among atrial peptides, renin, and blood volume in pregnant rats. Am J Physiol. 1988 May;254(5 Pt 2):R793–R800. doi: 10.1152/ajpregu.1988.254.5.R793. [DOI] [PubMed] [Google Scholar]
  23. Otsuki Y., Okamoto E., Iwata I., Nishino E., Mitsuda N., Mori M., Takagi T., Sugita N., Tanizawa O. Changes in concentration of human atrial natriuretic peptide in normal pregnancy and toxaemia. J Endocrinol. 1987 Aug;114(2):325–328. doi: 10.1677/joe.0.1140325. [DOI] [PubMed] [Google Scholar]
  24. Robson S. C., Hunter S., Moore M., Dunlop W. Haemodynamic changes during the puerperium: a Doppler and M-mode echocardiographic study. Br J Obstet Gynaecol. 1987 Nov;94(11):1028–1039. doi: 10.1111/j.1471-0528.1987.tb02286.x. [DOI] [PubMed] [Google Scholar]
  25. St-Louis J., Sicotte B. Prostaglandin- or endothelium-mediated vasodilation is not involved in the blunted responses of blood vessels to vasoconstrictors in pregnant rats. Am J Obstet Gynecol. 1992 Feb;166(2):684–692. doi: 10.1016/0002-9378(92)91698-a. [DOI] [PubMed] [Google Scholar]
  26. Steegers E. A., van Lakwijk H. P., Fast J. H., Godschalx A. W., Jongsma H. W., Eskes T. K., Symonds E. M., Hein P. R. Atrial natriuretic peptide and atrial size during normal pregnancy. Br J Obstet Gynaecol. 1991 Feb;98(2):202–206. doi: 10.1111/j.1471-0528.1991.tb13369.x. [DOI] [PubMed] [Google Scholar]
  27. Taya K., Greenwald G. S. In vivo and in vitro ovarian steroidogenesis in the pregnant rat. Biol Reprod. 1981 Nov;25(4):683–691. doi: 10.1095/biolreprod25.4.683. [DOI] [PubMed] [Google Scholar]
  28. de Bold A. J., Borenstein H. B., Veress A. T., Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981 Jan 5;28(1):89–94. doi: 10.1016/0024-3205(81)90370-2. [DOI] [PubMed] [Google Scholar]

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