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. 1982 May 1;203(2):511–513. doi: 10.1042/bj2030511

The inhibitory effect of Zn2+ on poly(ADP-ribose) polymerase activity and its reversal.

A G Larsen, A C Ostvold, J Holtlund, T Kristensen, S G Laland
PMCID: PMC1158257  PMID: 6288004

Abstract

Zn2+ inhibits purified poly(ADP-ribose) polymerase (50% inhibition at 10 microM). Furthermore poly (ADP-ribose) polymerase present in nuclei and metaphase chromosome clusters is also inhibited by Zn2+. The inactivated enzyme could be re-activated by dithiothreitol. The concentration of Zn2+ needed to affect the enzyme activity in the organelles is sufficiently low for it to have a possible role in controlling the activity of this chromatin-bound enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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