Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1982 Jul 1;205(1):1–13. doi: 10.1042/bj2050001

Specific targets for antiviral drugs.

E De Clercq
PMCID: PMC1158439  PMID: 6181775

Full text

PDF
3

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allaudeen H. S., Chen M. S., Lee J. J., De Clercq E., Prusoff W. H. Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells. J Biol Chem. 1982 Jan 25;257(2):603–606. [PubMed] [Google Scholar]
  2. Allaudeen H. S., Kozarich J. W., Bertino J. R., De Clercq E. On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine. Proc Natl Acad Sci U S A. 1981 May;78(5):2698–2702. doi: 10.1073/pnas.78.5.2698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aswell J. F., Allen G. P., Jamieson A. T., Campbell D. E., Gentry G. A. Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro. Antimicrob Agents Chemother. 1977 Aug;12(2):243–254. doi: 10.1128/aac.12.2.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bader J. P., Brown N. R., Chiang P. K., Cantoni G. L. 3-Deazaadenosine, an inhibitor of adenosylhomocysteine hydrolase, inhibits reproduction of Rous sarcoma virus and transformation of chick embryo cells. Virology. 1978 Sep;89(2):494–505. doi: 10.1016/0042-6822(78)90191-5. [DOI] [PubMed] [Google Scholar]
  5. Benedetto A., Rossi G. B., Amici C., Belardelli F., Cioè L., Carruba G., Carrasco L. Inhibition of animal virus production by means of translation inhibitors unable to penetrate normal cells. Virology. 1980 Oct 15;106(1):123–132. doi: 10.1016/0042-6822(80)90227-5. [DOI] [PubMed] [Google Scholar]
  6. Blough H. A., Giuntoli R. L. Successful treatment of human genital herpes infections with 2-deoxy-D-glucose. JAMA. 1979 Jun 29;241(26):2798–2801. [PubMed] [Google Scholar]
  7. Bouloy M., Plotch S. J., Krug R. M. Globin mRNAs are primers for the transcription of influenza viral RNA in vitro. Proc Natl Acad Sci U S A. 1978 Oct;75(10):4886–4890. doi: 10.1073/pnas.75.10.4886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Carrasco L. Membrane leakiness after viral infection and a new approach to the development of antiviral agents. Nature. 1978 Apr 20;272(5655):694–699. doi: 10.1038/272694a0. [DOI] [PubMed] [Google Scholar]
  9. Cassiman J. J., De Clercq E., Jones A. S., Walker R. T., Van den Berghe H. Sister chromatid exchange induced by anti-herpes drugs. Br Med J (Clin Res Ed) 1981 Sep 26;283(6295):817–818. doi: 10.1136/bmj.283.6295.817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Chatterjee S., Bradac J., Hunter E. Effect of tunicamycin on cell fusion induced by Mason-Pfizer monkey virus. J Virol. 1981 May;38(2):770–776. doi: 10.1128/jvi.38.2.770-776.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Chen M. S., Prusoff W. H. Phosphorylation of 5-iodo-5'-amino-2',5',dideoxyuridine by herpes simplex virus type 1 encoded thymidine kinase. J Biol Chem. 1979 Oct 25;254(20):10449–10452. [PubMed] [Google Scholar]
  12. Chen M. S., Ward D. C., Prusoff W. H. Specific herpes simplex virus-induced incorporation of 5-iodo-5'-amino-2',5'-dideoxyuridine into deoxyribonucleic acid. J Biol Chem. 1976 Aug 25;251(16):4833–4838. [PubMed] [Google Scholar]
  13. Cheng Y. C., Dutschman G., De Clercq E., Jones A. S., Rahim S. G., Verhelst G., Walker R. T. Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins. Mol Pharmacol. 1981 Jul;20(1):230–233. [PubMed] [Google Scholar]
  14. Clercq E. D., Dann O. Diaryl amidine derivatives as oncornaviral DNA polymerase inhibitors. J Med Chem. 1980 Jul;23(7):787–795. doi: 10.1021/jm00181a016. [DOI] [PubMed] [Google Scholar]
  15. DE Clercq E., Descamps J., DE Somer P., Holyacute A. (S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity. Science. 1978 May 5;200(4341):563–565. doi: 10.1126/science.200.4341.563. [DOI] [PubMed] [Google Scholar]
  16. Dawson K. M., Stewart A., Stebbing N. Absence of significant antiviral effects of beta-gamma-methylene GTP on encephalomyocarditis virus infection of L cells and mice. J Gen Virol. 1979 Oct;45(1):237–240. doi: 10.1099/0022-1317-45-1-237. [DOI] [PubMed] [Google Scholar]
  17. De Clercq E., Balzarini J., Descamps J., Huang G. F., Torrence P. F., Bergstrom D. E., Jones A. S., Serafinowski P., Verhelst G., Walker R. T. Antiviral, antimetabolic, and cytotoxic activities of 5-substituted 2'-deoxycytidines. Mol Pharmacol. 1982 Jan;21(1):217–223. [PubMed] [Google Scholar]
  18. De Clercq E., Descamps J., De Somer P., Barr P. J., Jones A. S., Walker R. T. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947–2951. doi: 10.1073/pnas.76.6.2947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. De Clercq E., Descamps J., Huang G. F., Torrence P. F. 5-Nitro-2'-deoxyuridine and 5-nitro-2'-deoxyuridine 5'-monophosphate: antiviral activity and inhibition of thymidylate synthetase in vivo. Mol Pharmacol. 1978 May;14(3):422–430. [PubMed] [Google Scholar]
  20. De Clercq E., Descamps J., Shugar D. 5-Propyl-2'-deoxyuridine: a specific anti-herpes agent. Antimicrob Agents Chemother. 1978 Mar;13(3):545–547. doi: 10.1128/aac.13.3.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. De Clercq E., Descamps J., Verhelst G., Walker R. T., Jones A. S., Torrence P. F., Shugar D. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus. J Infect Dis. 1980 May;141(5):563–574. doi: 10.1093/infdis/141.5.563. [DOI] [PubMed] [Google Scholar]
  22. De Clercq E., Leyten R., Sobis H., Matousek J., Holý A., De Somer P. Inhibitory effect of a broad-spectrum antiviral agent, (S)-9-(2,3-dihydroxypropyl)adenine, on spermatogenesis in mice. Toxicol Appl Pharmacol. 1981 Jul;59(3):441–451. doi: 10.1016/0041-008x(81)90296-9. [DOI] [PubMed] [Google Scholar]
  23. De Clercq E. New trends in antiviral chemotherapy. Arch Int Physiol Biochim. 1979 May;87(2):353–395. [PubMed] [Google Scholar]
  24. DeLong D. C., Reed S. E. Inhibition of rhinovirus replication in in organ culture by a potential antiviral drug. J Infect Dis. 1980 Jan;141(1):87–91. doi: 10.1093/infdis/141.1.87. [DOI] [PubMed] [Google Scholar]
  25. Descamps J., De Clercq E. Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells. J Biol Chem. 1981 Jun 25;256(12):5973–5976. [PubMed] [Google Scholar]
  26. Diana G. D., Salvador U. J., Zalay E. S., Carabateas P. M., Williams G. L., Collins J. C., Pancic F. Antiviral activity of some beta-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA viruses. J Med Chem. 1977 Jun;20(6):757–761. doi: 10.1021/jm00216a004. [DOI] [PubMed] [Google Scholar]
  27. Dobersen M. J., Jerkofsky M., Greer S. Enzymatic basis for the selective inhibition of varicella-zoster virus by 5-halogenated analogues of deoxycytidine. J Virol. 1976 Nov;20(2):478–486. doi: 10.1128/jvi.20.2.478-486.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Doetsch P. W., Suhadolnik R. J., Sawada Y., Mosca J. D., Flick M. B., Reichenbach N. L., Dang A. Q., Wu J. M., Charubala R., Pfleiderer W. Core (2'-5')oligoadenylate and the cordycepin analog: inhibitors of Epstein--Barr virus-induced transformation of human lymphocytes in the absence of interferon. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6699–6703. doi: 10.1073/pnas.78.11.6699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Drach J. C., Thomas M. A., Barnett J. W., Smith S. H., Shipman C., Jr Tritiated thymidine incorporation does not measure DNA synthesis in ribavirin-treated human cells. Science. 1981 May 1;212(4494):549–551. doi: 10.1126/science.7209549. [DOI] [PubMed] [Google Scholar]
  30. Dubovi E. J., Geratz J. D., Shaver S. R., Tidwell R. R. Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines. Antimicrob Agents Chemother. 1981 Apr;19(4):649–656. doi: 10.1128/aac.19.4.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Elion G. B., Furman P. A., Fyfe J. A., de Miranda P., Beauchamp L., Schaeffer H. J. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716–5720. doi: 10.1073/pnas.74.12.5716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Fischer P. H., Chen M. S., Prusoff W. H. The incorporation of 5-iodo-5'-amino-2',5-dideoxyuridine and 5-iodo-2'-deoxyuridine into herpes simplex virus DNA. Relationship between antiviral activity and effects on DNA structure. Biochim Biophys Acta. 1980 Feb 29;606(2):236–245. doi: 10.1016/0005-2787(80)90033-7. [DOI] [PubMed] [Google Scholar]
  33. Furman P. A., McGuirt P. V., Keller P. M., Fyfe J. A., Elion G. B. Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. Virology. 1980 Apr 30;102(2):420–430. doi: 10.1016/0042-6822(80)90109-9. [DOI] [PubMed] [Google Scholar]
  34. Furman P. A., St Clair M. H., Fyfe J. A., Rideout J. L., Keller P. M., Elion G. B. Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. J Virol. 1979 Oct;32(1):72–77. doi: 10.1128/jvi.32.1.72-77.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Fyfe J. A., Keller P. M., Furman P. A., Miller R. L., Elion G. B. Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine. J Biol Chem. 1978 Dec 25;253(24):8721–8727. [PubMed] [Google Scholar]
  36. Gentry G. A., Aswell J. F. Inhibition of herpes simplex virus replication by araT. Virology. 1975 May;65(1):294–296. doi: 10.1016/0042-6822(75)90034-3. [DOI] [PubMed] [Google Scholar]
  37. Goswami B. B., Borek E., Sharma O. K., Fujitaki J., Smith R. A. The broad spectrum antiviral agent ribavirin inhibits capping of mRNA. Biochem Biophys Res Commun. 1979 Aug 13;89(3):830–836. doi: 10.1016/0006-291x(79)91853-9. [DOI] [PubMed] [Google Scholar]
  38. Helgstrand E., Eriksson B., Johansson N. G., Lannerö B., Larsson A., Misiorny A., Norén J. O., Sjöberg B., Stenberg K., Stening G. Trisodium phosphonoformate, a new antiviral compound. Science. 1978 Sep 1;201(4358):819–821. doi: 10.1126/science.210500. [DOI] [PubMed] [Google Scholar]
  39. Jahrling P. B., Hesse R. A., Eddy G. A., Johnson K. M., Callis R. T., Stephen E. L. Lassa virus infection of rhesus monkeys: pathogenesis and treatment with ribavirin. J Infect Dis. 1980 May;141(5):580–589. doi: 10.1093/infdis/141.5.580. [DOI] [PubMed] [Google Scholar]
  40. Kato N., Eggers H. J. Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride. Virology. 1969 Apr;37(4):632–641. doi: 10.1016/0042-6822(69)90281-5. [DOI] [PubMed] [Google Scholar]
  41. Koff W. C., Knight V. Inhibition of influenza virus uncoating by rimantadine hydrochloride. J Virol. 1979 Jul;31(1):261–263. doi: 10.1128/jvi.31.1.261-263.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Kára J., Vácha P., Holý A. 9-(S)-(2,3-Dihydroxypropyl)adenine inhibits the transformation of chick embryo fibroblasts infected with Rous sarcoma virus: Evidence for inhibition of enzymatic activity of isolated cellular protein kinases by the drug. FEBS Lett. 1979 Nov 1;107(1):187–192. doi: 10.1016/0014-5793(79)80492-5. [DOI] [PubMed] [Google Scholar]
  43. Leavitt R., Schlesinger S., Kornfeld S. Tunicamycin inhibits glycosylation and multiplication of Sindbis and vesicular stomatitis viruses. J Virol. 1977 Jan;21(1):375–385. doi: 10.1128/jvi.21.1.375-385.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Leinbach S. S., Reno J. M., Lee L. F., Isbell A. F., Boezi J. A. Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase. Biochemistry. 1976 Jan 27;15(2):426–430. doi: 10.1021/bi00647a029. [DOI] [PubMed] [Google Scholar]
  45. Lopez C., Watanabe K. A., Fox J. J. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980 May;17(5):803–806. doi: 10.1128/aac.17.5.803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Machida H., Ichikawa M., Kuninaka A., Saneyoshi M., Yoshino H. Effect of treatment with 1-beta-D-arabinofuranosylthymine of experimental encephalitis induced by herpes simplex virus in mice. Antimicrob Agents Chemother. 1980 Feb;17(2):109–114. doi: 10.1128/aac.17.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Matsukage A., Ono K., Ohashi A., Takahashi T., Nakayama C., Saneyoshi M. Inhibitory effect of 1-beta-D-arabinofuranosylthymine 5'-triphosphate and 1-beta-D-arabinofuranosylcytosine 5'-triphosphate on DNA polymerases from murine cells and oncornavirus. Cancer Res. 1978 Sep;38(9):3076–3079. [PubMed] [Google Scholar]
  48. Maudgal P. C., Missotten L., De Clercq E., Descamps J., De Meuter E. Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(4):261–268. doi: 10.1007/BF00455033. [DOI] [PubMed] [Google Scholar]
  49. McSharry J. J., Caliguiri L. A., Eggers H. J. Inhibition of uncoating of poliovirus by arildone, a new antiviral drug. Virology. 1979 Sep;97(2):307–315. doi: 10.1016/0042-6822(79)90342-8. [DOI] [PubMed] [Google Scholar]
  50. Miller W. H., Miller R. L. Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase. J Biol Chem. 1980 Aug 10;255(15):7204–7207. [PubMed] [Google Scholar]
  51. Mitchell C. D., Bean B., Gentry S. R., Groth K. E., Boen J. R., Balfour H. H., Jr Acyclovir therapy for mucocutaneous herpes simplex infections in immunocompromised patients. Lancet. 1981 Jun 27;1(8235):1389–1392. doi: 10.1016/s0140-6736(81)92569-1. [DOI] [PubMed] [Google Scholar]
  52. Morrison T. G., McQuain C. O., Simpson D. Assembly of viral membranes: maturation of the vesicular stomatitis virus glycoprotein in the presence of tunicamycin. J Virol. 1978 Oct;28(1):368–374. doi: 10.1128/jvi.28.1.368-374.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Müller W. E., Zahn R. K., Arendes F., Falke D. Phosphorylation of arabinofuranosylthymine in non-infected and herpesvirus (TK+ and TK-)-infected cells. J Gen Virol. 1979 May;43(2):261–271. doi: 10.1099/0022-1317-43-2-261. [DOI] [PubMed] [Google Scholar]
  54. Norrby E. The effect of a carbobenzoxy tripeptide on the biological activities of measles virus. Virology. 1971 Jun;44(3):599–608. doi: 10.1016/0042-6822(71)90374-6. [DOI] [PubMed] [Google Scholar]
  55. Pancic F., Steinberg B. A., Diana G. D., Carabateas P. M., Gorman W. G., Came P. E. Antiviral activity of Win 41258-3, a pyrazole compound, against herpes simplex virus in mouse genital infection and in guinea pig skin infection. Antimicrob Agents Chemother. 1981 Mar;19(3):470–476. doi: 10.1128/aac.19.3.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Pelling J. C., Drach J. C., Shipman C., Jr Internucleotide incorporation of arabinosyladenine into herpes simplex virus and mammalian cell DNA. Virology. 1981 Mar;109(2):323–335. doi: 10.1016/0042-6822(81)90503-1. [DOI] [PubMed] [Google Scholar]
  57. Peterslund N. A., Seyer-Hansen K., Ipsen J., Esmann V., Schonheyder H., Juhl H. Acyclovir in herpes zoster. Lancet. 1981 Oct 17;2(8251):827–830. doi: 10.1016/s0140-6736(81)91102-8. [DOI] [PubMed] [Google Scholar]
  58. Plotch S. J., Bouloy M., Krug R. M. Transfer of 5'-terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitro. Proc Natl Acad Sci U S A. 1979 Apr;76(4):1618–1622. doi: 10.1073/pnas.76.4.1618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Prusoff W. H., Goz B. Potential mechanisms of action of antiviral agents. Fed Proc. 1973 Jun;32(6):1679–1687. [PubMed] [Google Scholar]
  60. Radsak K. D., Weder D. Effect of 2-deoxy-D-glucose on cytomegalovirus-induced DNA synthesis in human fibroblasts. J Gen Virol. 1981 Nov;57(Pt 1):33–42. doi: 10.1099/0022-1317-57-1-33. [DOI] [PubMed] [Google Scholar]
  61. Richardson C. D., Scheid A., Choppin P. W. Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 or HA2 viral polypeptides. Virology. 1980 Aug;105(1):205–222. doi: 10.1016/0042-6822(80)90168-3. [DOI] [PubMed] [Google Scholar]
  62. Saral R., Burns W. H., Laskin O. L., Santos G. W., Lietman P. S. Acyclovir prophylaxis of herpes-simplex-virus infections. N Engl J Med. 1981 Jul 9;305(2):63–67. doi: 10.1056/NEJM198107093050202. [DOI] [PubMed] [Google Scholar]
  63. Schildkraut I., Cooper G. M., Greer S. Selective inhibition of the replication of herpes simplex virus by 5-halogenated analogues of deoxycytidine. Mol Pharmacol. 1975 Mar;11(2):153–158. [PubMed] [Google Scholar]
  64. Selby P. J., Powles R. L., Janeson B., Kay H. E., Watson J. G., Thornton R., Morgenstern G., Clink H. M., McElwain T. J., Prentice H. G. Parenteral acyclovir therapy for herpesvirus infections in man. Lancet. 1979 Dec 15;2(8155):1267–1270. doi: 10.1016/s0140-6736(79)92281-5. [DOI] [PubMed] [Google Scholar]
  65. Skehel J. J., Hay A. J., Armstrong J. A. On the mechanism of inhibition of influenza virus replication by amantadine hydrochloride. J Gen Virol. 1978 Jan;38(1):97–110. doi: 10.1099/0022-1317-38-1-97. [DOI] [PubMed] [Google Scholar]
  66. Smith C. B., Charette R. P., Fox J. P., Cooney M. K., Hall C. E. Lack of effect of oral ribavirin in naturally occurring influenza A virus (H1N1) infection. J Infect Dis. 1980 May;141(5):548–554. doi: 10.1093/infdis/141.5.548. [DOI] [PubMed] [Google Scholar]
  67. Streeter D. G., Witkowski J. T., Khare G. P., Sidwell R. W., Bauer R. J., Robins R. K., Simon L. N. Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1174–1178. doi: 10.1073/pnas.70.4.1174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Sundquist B., Oberg B. Phosphonoformate inhibits reverse transcriptase. J Gen Virol. 1979 Nov;45(2):273–281. doi: 10.1099/0022-1317-45-2-273. [DOI] [PubMed] [Google Scholar]
  69. Tamm I., Eggers H. J., Bablanian R., Wagner A. F., Folkers K. Structural requirements of selective inhibition of enteroviruses by 2-(alpha-hydroxybenzyl)-benzimidazole and related compounds. Nature. 1969 Aug 23;223(5208):785–788. doi: 10.1038/223785a0. [DOI] [PubMed] [Google Scholar]
  70. Tidwell R. R., Geratz J. D., Dann O., Volz G., Zeh D., Loewe H. Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. J Med Chem. 1978 Jul;21(7):613–623. doi: 10.1021/jm00205a005. [DOI] [PubMed] [Google Scholar]
  71. Watanabe K. A., Reichman U., Hirota K., Lopez C., Fox J. J. Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides. J Med Chem. 1979 Jan;22(1):21–24. doi: 10.1021/jm00187a005. [DOI] [PubMed] [Google Scholar]
  72. Zamecnik P. C., Stephenson M. L. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci U S A. 1978 Jan;75(1):280–284. doi: 10.1073/pnas.75.1.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. de Clercq E., Degreef H., Wildiers J., de Jonge G., Drochmans A., Descamps J., de Somer P. Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine in severe herpes zoster. Br Med J. 1980 Nov 1;281(6249):1178–1178. doi: 10.1136/bmj.281.6249.1178. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES