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. 1982 Aug 1;205(2):381–388. doi: 10.1042/bj2050381

The kinetic mechanism of the major form of ox kidney aldehyde reductase with d-glucuronic acid

Ann K Daly 1, Timothy J Mantle 1
PMCID: PMC1158491  PMID: 6814425

Abstract

The steady-state kinetics of the major form of ox kidney aldehyde reductase with d-glucuronic acid have been determined at pH7. Initial rate and product inhibition studies performed in both directions are consistent with a Di-Iso Ordered Bi Bi mechanism. The mechanism of inhibition by sodium valproate and benzoic acid is shown to involve flux through an alternative pathway.

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Selected References

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