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. 1982 Aug 15;206(2):295–299. doi: 10.1042/bj2060295

Evidence for a direct effect of bacitracin on cell-mediated insulin degradation in isolated hepatocytes

Sandra M Juul 1, Richard H Jones 1
PMCID: PMC1158585  PMID: 6756390

Abstract

In freshly isolated hepatocytes, in which extracellular degradation of insulin was very low, the degradation velocity was first-order with respect to the amount of insulin bound at steady state. The addition of bacitracin decreased the degradation velocity considerably, so that a higher proportion of cell-associated radioactivity remained intact. The results demonstrate that bacitracin affects the mechanism of insulin processing by intact hepatocytes.

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Selected References

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