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. 1982 Sep 15;206(3):627–631. doi: 10.1042/bj2060627

Acute effects of glucagon on citrulline biosynthesis.

D Rabier, P Briand, F Petit, P Parvy, P Kamoun, L Cathelineau
PMCID: PMC1158632  PMID: 7150266

Abstract

Mitochondria isolated from livers of rats fed on different diets showed altered capacity to synthesize citrulline. Glucagon, 15 min after injection, increases citrulline biosynthesis, except after the high-protein diet. A significant correlation between citrulline biosynthesis and N-acetylglutamate content with and without glucagon treatment was shown when rats were fed on a standard or a carbohydrate diet. Different diets modified carbamoyl phosphate synthetase I (EC 6.3.4.16) and N-acetylglutamate synthase (acetyl-CoA:L-glutamate N-acetyltransferase, EC 2.3.1.1) activities. Glucagon did not modify these activities.

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Selected References

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