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. 1982 Sep 15;206(3):641–645. doi: 10.1042/bj2060641

Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles

Josephine A McGrath *, David F Goldspink †
PMCID: PMC1158634  PMID: 7150268

Abstract

The direct actions of glucocorticoid hormones on protein turnover were studied in isolated soleus muscles. These steroids were found to decrease the rates of both protein synthesis and protein breakdown within 3 h and 4 h respectively. Synthetic steroids (e.g. dexamethasone) were found to be more potent than naturally secreted hormones (e.g. cortisol) in inducing these changes, but only at concentrations in vitro less than 10nm.

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Selected References

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