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. 1979 Jun 15;180(3):689–692. doi: 10.1042/bj1800689

Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin.

L Agius, A M Robinson, J R Girard, D H Williamson
PMCID: PMC1161113  PMID: 486145

Abstract

Removal of pups for 24 h from rats at peak lactation decreased 3H2O incorporation into lipid in vivo in mammary gland by 95%, whereas it was increased in liver (77%) and adipose tissue (330%). These increases were prevented by administration of prolactin. Plasma insulin increased 3-fold on weaning and this was partially prevented by prolactin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amenomori Y., Chen C. L., Meites J. Serum prolactin levels in rats during different reproductive states. Endocrinology. 1970 Mar;86(3):506–510. doi: 10.1210/endo-86-3-506. [DOI] [PubMed] [Google Scholar]
  2. Benito M., Williamson D. H. Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating rats. Biochem J. 1978 Oct 15;176(1):331–334. doi: 10.1042/bj1760331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brunengraber H., Boutry M., Lowenstein J. M. Fatty acid and 3- -hydroxysterol synthesis in the perfused rat liver. Including measurements on the production of lactate, pyruvate, -hydroxy-butyrate, and acetoacetate by the fed liver. J Biol Chem. 1973 Apr 25;248(8):2656–2669. [PubMed] [Google Scholar]
  4. Hamosh M., Clary T. R., Chernick S. S., Scow R. O. Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride in pregnant and lactating rats. Biochim Biophys Acta. 1970 Sep 8;210(3):473–482. doi: 10.1016/0005-2760(70)90044-5. [DOI] [PubMed] [Google Scholar]
  5. Hanwell A., Linzell J. L. The effects of engorgement with milk and of suckling on mammary blood flow in the rat. J Physiol. 1973 Aug;233(1):111–125. doi: 10.1113/jphysiol.1973.sp010300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hwang P., Guyda H., Friesen H. Purification of human prolactin. J Biol Chem. 1972 Apr 10;247(7):1955–1958. [PubMed] [Google Scholar]
  7. Jungas R. L. Fatty acid synthesis in adipose tissue incubated in tritiated water. Biochemistry. 1968 Oct;7(10):3708–3717. doi: 10.1021/bi00850a050. [DOI] [PubMed] [Google Scholar]
  8. Katz J., Wals P. A., Van de Velde R. L. Lipogenesis by acini from mammary gland of lactating rats. J Biol Chem. 1974 Nov 25;249(22):7348–7357. [PubMed] [Google Scholar]
  9. Robinson A. M., Girard J. R., Williamson D. H. Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding. Biochem J. 1978 Oct 15;176(1):343–346. doi: 10.1042/bj1760343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Robinson A. M., Williamson D. H. Comparison of glucose metabolism in the lactating mammary gland of the rat in vivo and in vitro. Effects of starvation, prolactin or insulin deficiency. Biochem J. 1977 Apr 15;164(1):153–159. doi: 10.1042/bj1640153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Romsos D. R., Muiruri K. L., Lin P. Y., Leveille G. A. Influence of dietary fat, fasting, and acute premature weaning on in vivo rates of fatty acid synthesis in lactating mice. Proc Soc Exp Biol Med. 1978 Nov;159(2):308–312. doi: 10.3181/00379727-159-40338. [DOI] [PubMed] [Google Scholar]
  12. Scanu A. M. Factors affecting lipoprotein metabolism. Adv Lipid Res. 1965;3:63–138. [PubMed] [Google Scholar]
  13. Seki M., Seki K., Yoshihara T., Watanabe N., Okumura T. Direct inhibition of pituitary LH secretion in rats by CB-154 (2-Br-alpha-ergocryptine). Endocrinology. 1974 Mar;94(3):911–914. doi: 10.1210/endo-94-3-911. [DOI] [PubMed] [Google Scholar]
  14. Smith R. W. The effects of pregnancy, lactation and involution on the metabolism of glucose and acetate by rat liver tissue. J Dairy Res. 1973 Oct;40(3):339–351. doi: 10.1017/s0022029900014710. [DOI] [PubMed] [Google Scholar]
  15. Smith R. W. The effects of pregnancy, lactation and involution on the metabolism of glucose by rat parametrial adipose tissue. J Dairy Res. 1973 Oct;40(3):353–360. doi: 10.1017/s0022029900014722. [DOI] [PubMed] [Google Scholar]
  16. Stansbie D., Brownsey R. W., Crettaz M., Denton R. M. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J. 1976 Nov 15;160(2):413–416. doi: 10.1042/bj1600413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Zinder O., Hamosh M., Fleck T. R., Scow R. O. Effect of prolactin on lipoprotein lipase in mammary glands and adipose tissue of rats. Am J Physiol. 1974 Mar;226(3):742–748. doi: 10.1152/ajplegacy.1974.226.3.744. [DOI] [PubMed] [Google Scholar]

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