Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1980 May 15;188(2):541–548. doi: 10.1042/bj1880541

Facilitated transport of amino acids across organic phases and the human erythrocyte membrane.

R C Hider, W McCormack
PMCID: PMC1161899  PMID: 7396879

Abstract

1. An artificial facilitated amino-acid-transfer process operating across a chloroform phase is reported. 2. This process utilizes a family of bis(salicylamidato)copper(II) complexes. 3. A mechanism is proposed for this process and for its sensitivity towards cyanide and bathophenanthroline sulphonate. 4. Facilitated transfer of L-leucine in human erythrocytes has been shown to be inhibited by bathophenanthroline sulphonate.

Full text

PDF
542

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chutkow J. G. Evidence for uptake of nonceruloplasminic copper in the brain: effect of ionic copper and amino acids. Proc Soc Exp Biol Med. 1978 May;158(1):113–116. doi: 10.3181/00379727-158-40152. [DOI] [PubMed] [Google Scholar]
  2. Eddy A. A., Hogg M. C. Further observations on the inhibitory effect of extracellular potassium ions on glycine uptake by mouse ascites-tumour cells. Biochem J. 1969 Oct;114(4):807–814. doi: 10.1042/bj1140807. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Harris D. I., Sass-Kortsak A. The influence of amino acids on copper uptake by rat liver slices. J Clin Invest. 1967 Apr;46(4):659–667. doi: 10.1172/JCI105567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hider R. C., Fern E. B., London D. R. Identification in skeletal muscle of a distinct extracellular pool of amino acids, and its role in protein synthesis. Biochem J. 1971 Mar;121(5):817–827. doi: 10.1042/bj1210817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hoare D. G. The temperature dependence of the transport of L-leucine in human erythrocytes. J Physiol. 1972 Mar;221(2):331–348. doi: 10.1113/jphysiol.1972.sp009754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lossen O. A sequential dialysis method for measuring permeability coefficients of phospholipid vesicles. Biochim Biophys Acta. 1972 Sep 1;282(1):31–39. doi: 10.1016/0005-2736(72)90308-2. [DOI] [PubMed] [Google Scholar]
  7. Neumann P. Z., Silverberg M. Active copper transport in mammalian tissues--a possible role in Wilson's disease. Nature. 1966 Apr 23;210(5034):414–416. doi: 10.1038/210414a0. [DOI] [PubMed] [Google Scholar]
  8. OXENDER D. L., CHRISTENSEN H. N. DISTINCT MEDIATING SYSTEMS FOR THE TRANSPORT OF NEUTRAL AMINO ACIDS BY THE EHRLICH CELL. J Biol Chem. 1963 Nov;238:3686–3699. [PubMed] [Google Scholar]
  9. PAL P. R., CHRISTENSEN H. N. Interrelationships in the cellular uptake of amino acids and metals. J Biol Chem. 1959 Mar;234(3):613–617. [PubMed] [Google Scholar]
  10. Pedersen C. J., Frensdorff H. K. Macrocyclic polyethers and their complexes. Angew Chem Int Ed Engl. 1972 Jan;11(1):16–25. doi: 10.1002/anie.197200161. [DOI] [PubMed] [Google Scholar]
  11. Pressman B. C. Properties of ionophores with broad range cation selectivity. Fed Proc. 1973 Jun;32(6):1698–1703. [PubMed] [Google Scholar]
  12. Schultz S. G., Yu-Tu L., Strecker C. K. Influx of neutral amino acids across the brush border of rabbit ileum. Stereospecificity and the roles of the -amino and -carboxylate groups. Biochim Biophys Acta. 1972 Nov 2;288(2):367–379. doi: 10.1016/0005-2736(72)90258-1. [DOI] [PubMed] [Google Scholar]
  13. WINTER C. G., CHRISTENSEN H. N. MIGRATION OF AMINO ACIDS ACROSS THE MEMBRANE OF THE HUMAN ERYTHROCYTE. J Biol Chem. 1964 Mar;239:872–878. [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES