Abstract
Lipogenesis in brown adipose tissue of virgin rats increased 8--10-fold after intragastric feeding with glucose or medium-chain triacylglycerol, and this increase was prevented by short-term insulin deficiency. Brown adipose tissue increased in weight during pregnancy, regressed during lactation and hypertrophied again on weaning; the rate of lipogenesis paralleled these changes. Glucose did not increase brown-adipose-tissue lipogenesis at mid-lactation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Agius L., Robinson A. M., Girard J. R., Williamson D. H. Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin. Biochem J. 1979 Jun 15;180(3):689–692. doi: 10.1042/bj1800689. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Depocas F., Behrens W. A. Levels of noradrenaline in plasma during thermogenesis induced by cold-exposure or by noradrenaline infusion in warm- and in cold-acclimated rats. Experientia Suppl. 1978;32:135–146. doi: 10.1007/978-3-0348-5559-4_15. [DOI] [PubMed] [Google Scholar]
- Flint D. J., Sinnett-Smith P. A., Clegg R. A., Vernon R. G. Role of insulin receptors in the changing metabolism of adipose tissue during pregnancy and lactation in the rat. Biochem J. 1979 Aug 15;182(2):421–427. doi: 10.1042/bj1820421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foster D. O., Frydman M. L. Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. Can J Physiol Pharmacol. 1979 Mar;57(3):257–270. doi: 10.1139/y79-039. [DOI] [PubMed] [Google Scholar]
- Himms-Hagen J. Obesity may be due to a malfunctioning of brown fat. Can Med Assoc J. 1979 Nov 17;121(10):1361–1364. [PMC free article] [PubMed] [Google Scholar]
- McCormack J. G., Denton R. M. Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase. Biochem J. 1977 Sep 15;166(3):627–630. doi: 10.1042/bj1660627. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rath E. A., Salmon D. M., Hems D. A. Effect of acute change in ambient temperature on fatty acid synthesis in the mouse. FEBS Lett. 1979 Dec 1;108(1):33–36. doi: 10.1016/0014-5793(79)81172-2. [DOI] [PubMed] [Google Scholar]
- Rothwell N. J., Stock M. J. A role for brown adipose tissue in diet-induced thermogenesis. Nature. 1979 Sep 6;281(5726):31–35. doi: 10.1038/281031a0. [DOI] [PubMed] [Google Scholar]
- Schein P. S., Alberti K. G., Williamson D. H. Effects of streptozotocin on carbohydrate and lipid metabolism in the rat. Endocrinology. 1971 Sep;89(3):827–834. doi: 10.1210/endo-89-3-827. [DOI] [PubMed] [Google Scholar]
- Smith R. W., Walsh A. Effect of lactation on lipolysis in rat adipose tissue. Lipids. 1976 May;11(5):418–420. doi: 10.1007/BF02532850. [DOI] [PubMed] [Google Scholar]
- Stansbie D., Brownsey R. W., Crettaz M., Denton R. M. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J. 1976 Nov 15;160(2):413–416. doi: 10.1042/bj1600413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Trayhurn P. Fatty acid synthesis in vivo in brown adipose tissue, liver and white adipose tissue of the cold-acclimated rat. FEBS Lett. 1979 Aug 1;104(1):13–16. doi: 10.1016/0014-5793(79)81075-3. [DOI] [PubMed] [Google Scholar]
- Yeh Y. Y., Zee P. Relation of ketosis to metabolic changes induced by acute medium-chain triglyceride feeding in rats. J Nutr. 1976 Jan;106(1):58–67. doi: 10.1093/jn/106.1.58. [DOI] [PubMed] [Google Scholar]