Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1980 Oct 15;192(1):361–364. doi: 10.1042/bj1920361

Rapid inhibition of lipogenesis in vivo in lactating rat mammary gland by medium- or long-chain triacylglycerols and partial reversal by insulin.

L Agius, D H Williamson
PMCID: PMC1162342  PMID: 7030306

Abstract

An intragastric load of medium- or long-chain triacylglycerols inhibited lipogenesis in lactating rat mammary gland in vivo by 82 or 89% respectively. This inhibition was reversed partially by insulin administration. Long-chain triacylglycerols inhibited hepatic lipogenesis in vivo but medium-chain triacylglycerols increased it 2-fold. Glucose utilization in vitro by mammary gland acini from triacylglycerol-fed rat was normal.

Full text

PDF
364

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agius L., Rolls B. J., Rowe E. A., Williamson D. H. Impaired lipogenesis in mammary glands of lactating rats fed on a cafeteria diet. Reversal of inhibition of glucose metabolism in vitro by insulin. Biochem J. 1980 Mar 15;186(3):1005–1008. doi: 10.1042/bj1861005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Agius L., Williamson D. H. Lipogenesis in interscapular brown adipose tissue of virgin, pregnant and lactating rats. The effects of intragastric feeding. Biochem J. 1980 Aug 15;190(2):477–480. doi: 10.1042/bj1900477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baxter M. A., Coore H. G. The mode of regulation of pyruvate dehydrogenase of lactating rat mammary gland. Effects of starvation and insulin. Biochem J. 1978 Aug 15;174(2):553–561. doi: 10.1042/bj1740553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coniglio J. G., Bridges R. The effect of dietary fat on fatty acid synthesis in cell-free preparations of lactating mammary gland. Lipids. 1966 Jan;1(1):76–80. doi: 10.1007/BF02668127. [DOI] [PubMed] [Google Scholar]
  5. DILS R., POPJAK G. Biosynthesis of fatty acids in cell-free preparations. 5. Synthesis of fatty acids from acetate in extracts of lactating-rat mammary gland. Biochem J. 1962 Apr;83:41–51. doi: 10.1042/bj0830041. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GARTON G. A. THE COMPOSITION AND BIOSYNTHESIS OF MILK LIPIDS. J Lipid Res. 1963 Jul;4:237–254. [PubMed] [Google Scholar]
  7. Grigor M. R., Warren S. M. Dietary regulation of mammary lipogenesis in lactating rats. Biochem J. 1980 Apr 15;188(1):61–65. doi: 10.1042/bj1880061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. KRITCHEVSKY D., TEPPER S. A. INFLUENCE OF MEDIUM-CHAIN TRIGLYCERIDE (MCT) ON CHOLESTEROL METABOLISM IN RATS. J Nutr. 1965 May;86:67–72. doi: 10.1093/jn/86.1.67. [DOI] [PubMed] [Google Scholar]
  9. Robinson A. M., Girard J. R., Williamson D. H. Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding. Biochem J. 1978 Oct 15;176(1):343–346. doi: 10.1042/bj1760343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Robinson A. M., Williamson D. H. Comparison of glucose metabolism in the lactating mammary gland of the rat in vivo and in vitro. Effects of starvation, prolactin or insulin deficiency. Biochem J. 1977 Apr 15;164(1):153–159. doi: 10.1042/bj1640153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Romsos D. R., Muiruri K. L., Lin P. Y., Leveille G. A. Influence of dietary fat, fasting, and acute premature weaning on in vivo rates of fatty acid synthesis in lactating mice. Proc Soc Exp Biol Med. 1978 Nov;159(2):308–312. doi: 10.3181/00379727-159-40338. [DOI] [PubMed] [Google Scholar]
  12. Stansbie D., Brownsey R. W., Crettaz M., Denton R. M. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J. 1976 Nov 15;160(2):413–416. doi: 10.1042/bj1600413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wiley J. H., Leveille G. A. Metabolic consequences of dietary medium-chain triglycerides in the rat. J Nutr. 1973 Jun;103(6):829–835. doi: 10.1093/jn/103.6.829. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES