Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1981 May 15;196(2):633–636. doi: 10.1042/bj1960633

Glucose turnover during pregnancy in anaesthetized post-absorptive rats

Armelle Leturque 1, Marc Gilbert 1, Jean Girard 1,*
PMCID: PMC1163039  PMID: 7317001

Abstract

During pregnancy the decline in blood [glucose] does not result from the increased distribution space of glucose. The absolute rate of glucose turnover increases in late pregnancy in parallel with the rise in the mass of the conceptus. Nevertheless, glucose turnover per kg body wt. is not increased in late pregnancy, since the lower blood [glucose] decreases glucose utilization by maternal tissues.

Full text

PDF
634

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abstracts: annual meeting--1979 Midwest Society for Pediatric Research, October 30 and 31, Cincinnati. J Pediatr. 1980 Jun;96(6):1105–1119. [PubMed] [Google Scholar]
  2. BERGMAN E. N. Quantitative aspects of glucose metabolism in pregnant and nonpregnant sheep. Am J Physiol. 1963 Jan;204:147–152. doi: 10.1152/ajplegacy.1963.204.1.147. [DOI] [PubMed] [Google Scholar]
  3. BLEICHER S. J., O'SULLIVAN J. B., FREINKEL N. CARBOHYDRATE METABOLISM IN PREGNANCY. V. THE INTERRELATIONS OF GLUCOSE, INSULIN AND FREE FATTY ACIDS IN LATE PREGNANCY AND POST PARTUM. N Engl J Med. 1964 Oct 22;271:866–872. doi: 10.1056/NEJM196410222711702. [DOI] [PubMed] [Google Scholar]
  4. Bergman E. N., Brockman R. P., Kaufman C. F. Glucose metabolism in ruminants: comparison of whole-body turnover with production by gut, liver, and kidneys. Fed Proc. 1974 Jul;33(7):1849–1854. [PubMed] [Google Scholar]
  5. Cherrington A. D., Williams P. E., Harris M. S. Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism. 1978 Jul;27(7):787–791. doi: 10.1016/0026-0495(78)90213-5. [DOI] [PubMed] [Google Scholar]
  6. Cousins L., Rigg L., Hollingsworth D., Brink G., Aurand J., Yen S. S. The 24-hour excursion and diurnal rhythm of glucose, insulin, and C-peptide in normal pregnancy. Am J Obstet Gynecol. 1980 Feb 15;136(4):483–488. doi: 10.1016/0002-9378(80)90675-4. [DOI] [PubMed] [Google Scholar]
  7. FELL B. F., SMITH K. A., CAMPBELL R. M. Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat. J Pathol Bacteriol. 1963 Jan;85:179–188. doi: 10.1002/path.1700850117. [DOI] [PubMed] [Google Scholar]
  8. Felig P. Maternal and fetal fuel homeostasis in human pregnancy. Am J Clin Nutr. 1973 Sep;26(9):998–1005. doi: 10.1093/ajcn/26.9.998. [DOI] [PubMed] [Google Scholar]
  9. Girard J. R., Cuendet G. S., Marliss E. B., Kervran A., Rieutort M., Assan R. Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat. J Clin Invest. 1973 Dec;52(12):3190–3200. doi: 10.1172/JCI107519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Herrera E., Knopp R. H., Freinkel N. Carbohydrate metabolism in pregnancy. VI. Plasma fuels, insulin, liver composition, gluconeogenesis, and nitrogen metabolism during late gestation in the fed and fasted rat. J Clin Invest. 1969 Dec;48(12):2260–2272. doi: 10.1172/JCI106192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kalhan S. C., D'Angelo L. J., Savin S. M., Adam P. A. Glucose production in pregnant women at term gestation. Sources of glucose for human fetus. J Clin Invest. 1979 Mar;63(3):388–394. doi: 10.1172/JCI109314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Katz J., Golden S., Dunn A., Chenoweth M. Estimation of glucose turnover in rats in vivo with tritium labeled glucoses. Hoppe Seylers Z Physiol Chem. 1976 Dec;357(10):1387–1394. doi: 10.1515/bchm2.1976.357.2.1387. [DOI] [PubMed] [Google Scholar]
  13. Knopp R. H., Boroush M. A., O'Sullivan J. B. Lipid metabolism in pregnancy. II. Postheparin lipolytic acitivity and hypertriglyceridemia in the pregnant rat. Metabolism. 1975 Apr;24(4):481–493. doi: 10.1016/0026-0495(75)90073-6. [DOI] [PubMed] [Google Scholar]
  14. Knopp R. H., Saudek C. D., Arky R. A., O'Sullivan J. B. 2 phases of adipose tissue metabolism in pregnancy: maternal adaptations for fetal growth. Endocrinology. 1973 Apr;92(4):984–988. doi: 10.1210/endo-92-4-984. [DOI] [PubMed] [Google Scholar]
  15. Meschia G., Battaglia F. C., Hay W. W., Sparks J. W. Utilization of substrates by the ovine placenta in vivo. Fed Proc. 1980 Feb;39(2):245–249. [PubMed] [Google Scholar]
  16. SCOW R. O., CHERNICK S. S., BRINLEY M. S. HYPERLIPEMIA AND KETOSIS IN THE PREGNANT RAT. Am J Physiol. 1964 Apr;206:796–804. doi: 10.1152/ajplegacy.1964.206.4.796. [DOI] [PubMed] [Google Scholar]
  17. SILVERSTONE F. A., SOLOMONS E., RUBRICIUS J. The rapid intravenous glucose tolerance test in pregnancy. J Clin Invest. 1961 Dec;40:2180–2189. doi: 10.1172/JCI104444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Victor A. Normal blood sugar variation during pregnancy. Acta Obstet Gynecol Scand. 1974;53(1):37–40. doi: 10.3109/00016347409156886. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES