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. 1981 Nov 15;200(2):461–464. doi: 10.1042/bj2000461

Alkaline phosphatase protein increases in response to prednisolone in HeLa cells.

W C Hanford, R H Kottel, W H Fishman
PMCID: PMC1163560  PMID: 7340849

Abstract

Quantification of term-placental alkaline phosphatase isoenzyme protein in HeLa TCRC-1 cells grown in the presence and absence of prednisolone indicates that there is a net increase in amount of enzyme-specific protein in prednisolone-stimulated cells. In a similar analysis of HeLa D98AH2 cells, prednisolone treatment causes the appearance of term-placental alkaline phosphatase protein and the loss of the intestinal isoenzyme protein. These results support the interpretation that the response of these cells to corticosteroids is the net accumulation of alkaline phosphatase protein rather than the modification of pre-existing enzyme to a more active state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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