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. 1976 Jun 15;156(3):515–520. doi: 10.1042/bj1560515

Glucagon-like and insulin-like hormones of the insect neurosecretory system.

H S Tager, J Markese, K J Kramer, R D Speirs, C N Childs
PMCID: PMC1163783  PMID: 949334

Abstract

Aqueous extracts of corpus cardiacum-corpus allatum complexes of the adult tobacco hornworm Manduca sexta produced both glycogenolysis and hypoglycaemia when injected into the larval form of the same species. Application of specific radioimmuno assays to similar extracts showed also that these gland complexes contain both glucagon-like and insulin-like peptides. Further, the partially purified immunoreactive peptides had the expected biological activities. The former decreased the glycogen content of the fatbody and the latter the circulating trehalose levels in recipient animals. These results suggest the existence of hormones in these invertebrates having both biological and structural similarities to vertebrate insulin and glucagon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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