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. 1977 Mar 15;162(3):617–626. doi: 10.1042/bj1620617

Metabolism of glucose, fructose and lactate in vivo in chronically cannulated foetuses and in suckling lambs.

D M Warnes, R F Seamark, F J Ballard
PMCID: PMC1164645  PMID: 869907

Abstract

1. Chronically cannulated sheep foetuses and suckling lambs were injected with 14C-labelled glucose, fructose or lactate, and sequential blood samples taken under conditions of minimal stress and without anaesthesia. 2. Gluconeogenesis from lactate was not detectable in foetal sheep, but the pathway was active in suckling lambs. 3. Fructose utilization rates were low in foetal sheep, with no measurable conversion into glucose or lactate. 4. The high rates of irreversible loss of both glucose and lactate in the foetus were decreased in suckling lambs. Radioactivity from labelled glucose entered both the lactate and fructose pools in foetal sheep, and entered the lactate pool in suckling lambs. 5. A model is proposed in which carbon flow between glucose, fructose and lactate has been quantified in foetal sheep.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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