Abstract
The incubation of nitrosobenzene with yeast transketolase and D-xylulose 5-phosphate resulted in the production of N-phenylglycolhydroxamic acid. The addition of D-ribose 5-phosphate decreased the amount of hydroxamic acid that was produced. This conversion of nitrosobenzene into the glycollic acid-derived hydroxamic acid was shown to be an enzymic process, and a chemical mechanism for the conversion was proposed.
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Selected References
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- Corbett M. D., Cahoy J. E., Chipko B. R. Conversion of nitrosobenzene to N-phenylacetohydroxamic acid by yeast pyruvate decarboxylase. J Natl Cancer Inst. 1975 Nov;55(5):1247–1248. doi: 10.1093/jnci/55.5.1247. [DOI] [PubMed] [Google Scholar]
- Kadlubar F. F., Miller J. A., Miller E. C. Microsomal N-oxidation of the hepatocarcinogen N-methyl-4-aminoazobenzene and the reactivity of N-hydroxy-N-methyl-4-aminoazobenzene. Cancer Res. 1976 Mar;36(3):1196–1206. [PubMed] [Google Scholar]
- Kiese M., Taeger K. The fate of phenylhydroxylamine in human red cells. Naunyn Schmiedebergs Arch Pharmacol. 1976;292(1):59–66. doi: 10.1007/BF00506490. [DOI] [PubMed] [Google Scholar]
- King C. M., Traub N. R., Cardona R. A., Howard R. B. Comparative adduct formation of 4-aminobiphenyl and 2-aminofluorene derivatives with macromolecules of isolated liver parenchymal cells. Cancer Res. 1976 Jul;36(7 Pt 1):2374–2381. [PubMed] [Google Scholar]
- Radomski J. L., Rey A. A., Brill E. Evidence for a glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl in the urine of dogs given 4-aminobiphenyl. Cancer Res. 1973 Jun;33(6):1284–1289. [PubMed] [Google Scholar]
- Saitou S., Ozawa T., Tomita I. The purification and some properties of brewer's yeast apotransketolase. FEBS Lett. 1974 Mar 15;40(1):114–118. doi: 10.1016/0014-5793(74)80906-3. [DOI] [PubMed] [Google Scholar]
- Ullrich J., Ostrovsky Y. M., Eyzaguirre J., Holzer H. Thiamine pyrophosphate-catalyzed enzymatic decarboxylation of -oxo acids. Vitam Horm. 1970;28:365–398. doi: 10.1016/s0083-6729(08)60903-6. [DOI] [PubMed] [Google Scholar]