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. 1975 Jan;145(1):63–71. doi: 10.1042/bj1450063

Activation and inhibition of rabbit muscle pyruvate kinase by transition-metal ions.

S Ainsworth, N Macfarlane
PMCID: PMC1165187  PMID: 1238084

Abstract

The paper reports a comparative study of the effects of Mn2+, Ni2+ and Co2+ on the reaction of ADP with phosphoenolypyruvate when catalysed by K+-activated rabbit muscle pyruvate kinase. The activation and subsequent inhibition that occurs as the bivalent ion concentration is increased is taken as evidence that the substrates of the enzyme are phosphoenolypyruvate, uncomplexed ADP and free bivalent cation. Kinetic constants for the binding of the bivalent cation to the enzyme are reported.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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