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. 1973 Sep;135(1):249–251. doi: 10.1042/bj1350249

Evidence that chick tendon procollagen must be denatured to serve as substrate for proline hydroxylase (Short Communication)

Lois Murphy 1, Joel Rosenbloom 1
PMCID: PMC1165812  PMID: 4359922

Abstract

The ability of chick-embryo proline hydroxylase to hydroxylate [14C]proline-labelled procollagen was investigated between 23° and 37°C. The amount of hydroxy[14C]proline that could be formed increased sharply between 26° and 30°C. This corresponded to the temperature interval in which the [14C]procollagen substrate was thermally denatured, and the results therefore indicate that only denatured molecules can be hydroxylated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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