Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1974 Apr;140(1):111–114. doi: 10.1042/bj1400111

Regulation of hepatic lipogenesis by plasma free fatty acids: simultaneous studies on lipoprotein secretion, cholesterol synthesis, ketogenesis and gluconeogenesis (Short Communication)

Peter A Mayes 1, David L Topping 1,*
PMCID: PMC1167977  PMID: 4375470

Abstract

1. An inverse logarithmic relationship was found between lipogenesis and the concentration of serum free fatty acids perfusing the rat liver. 2. Increased concentrations of serum free fatty acids did not alter cholesterol synthesis, triglyceride secretion or increase gluconeogenesis. 3. No direct relationship was found between ketogenesis and either lipogenesis or gluconeogenesis.

Full text

PDF
111

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORTZ W. M., LYNEN F. THE INHIBITION OF ACETYL COA CARBOXYLASE BY LONG CHAIN ACYL COA DERIVATIVES. Biochem Z. 1963 Aug 14;337:505–509. [PubMed] [Google Scholar]
  2. Barth C. A., Hackenschmidt H. J., Weis E. E., Decker K. F. Influence of kynuremate on cholesterol and fatty acid synthesis in isolated perfused rat liver. J Biol Chem. 1973 Jan 25;248(2):738–739. [PubMed] [Google Scholar]
  3. Dorsey J. A., Porter J. W. The effect of palmityl coenzyme A on pigeon liver fatty acid synthetase. J Biol Chem. 1968 Jun 25;243(12):3512–3516. [PubMed] [Google Scholar]
  4. Exton J. H., Corbin J. G., Harper S. C. Control of gluconeogenesis in liver. V. Effects of fasting, diabetes, and glucagon on lactate and endogenous metabolism in the perfused rat liver. J Biol Chem. 1972 Aug 25;247(16):4996–5003. [PubMed] [Google Scholar]
  5. Exton J. H., Park C. R. Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats. J Biol Chem. 1967 Jun 10;242(11):2622–2636. [PubMed] [Google Scholar]
  6. Goodridge A. G. Regulation of fatty acid synthesis in isolated hepatocytes prepared from the livers of neonatal chicks. J Biol Chem. 1973 Mar 25;248(6):1924–1931. [PubMed] [Google Scholar]
  7. Halperin M. L., Robinson B. H., Fritz I. B. Effects of palmitoyl CoA on citrate and malate transport by rat liver mitochondria. Proc Natl Acad Sci U S A. 1972 Apr;69(4):1003–1007. doi: 10.1073/pnas.69.4.1003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lowenstein J. M. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem. 1971 Feb 10;246(3):629–632. [PubMed] [Google Scholar]
  9. MAYES P. A. Absence of a relation between lipogenesis and ketogenesis in vivo. Nature. 1959 Feb 21;183(4660):540–541. doi: 10.1038/183540a0. [DOI] [PubMed] [Google Scholar]
  10. McGarry J. D., Foster D. W. The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis. J Biol Chem. 1971 Feb 25;246(4):1149–1159. [PubMed] [Google Scholar]
  11. PORTER J. W., LONG R. W. A study of the role of palmityl coenzyme A in fatty acid synthesis by the pigeon liver system. J Biol Chem. 1958 Jul;233(1):20–25. [PubMed] [Google Scholar]
  12. Pande S. V., Mead J. F. Inhibition of enzyme activities by free fatty acids. J Biol Chem. 1968 Dec 10;243(23):6180–6185. [PubMed] [Google Scholar]
  13. STADIE W. C. Ketogenesis. Diabetes. 1958 May-Jun;7(3):173–180. doi: 10.2337/diab.7.3.173b. [DOI] [PubMed] [Google Scholar]
  14. Topping D. L., Mayes P. A. The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism. Biochem J. 1972 Jan;126(2):295–311. doi: 10.1042/bj1260295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. VAN BRUGGEN J. T., HUTCHENS T. T., CLAYCOMB C. K., CATHEY W. J., WEST E. S. The effect of fasting upon lipogenesis in the intact rat. J Biol Chem. 1952 May;196(1):389–394. [PubMed] [Google Scholar]
  16. Wieland O. H., Patzelt C., Löffler G. Active and inactive forms of pyruvate dehydrogenase in rat liver. Effect of starvation and refeeding and of insulin treatment on pyruvate-dehydrogenase interconversion. Eur J Biochem. 1972 Apr 11;26(3):426–433. doi: 10.1111/j.1432-1033.1972.tb01783.x. [DOI] [PubMed] [Google Scholar]
  17. Williamson D. H., Bates M. W., Krebs H. A. Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver. Biochem J. 1968 Jul;108(3):353–361. doi: 10.1042/bj1080353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Williamson J. R., Kreisberg R. A., Felts P. W. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci U S A. 1966 Jul;56(1):247–254. doi: 10.1073/pnas.56.1.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Windmueller H. G., Spaeth A. E. De novo synthesis of fatty acid in perfused rat liver as a determinant of plasma lipoprotein production. Arch Biochem Biophys. 1967 Nov;122(2):362–369. doi: 10.1016/0003-9861(67)90206-8. [DOI] [PubMed] [Google Scholar]
  20. Windmueller H. G., Spaeth A. E. Perfusion in situ with tritium oxide to measure hepatic lipogenesis and lipid secretion. Normal and orotic acid-fed rats. J Biol Chem. 1966 Jun 25;241(12):2891–2899. [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES