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. 1974 Nov;143(2):483–486. doi: 10.1042/bj1430483

Stabilization of two-stranded ribohomopolymer helices and destabilization of a three-stranded helix by ethidium bromide (Short Communication)

Michael J Waring 1
PMCID: PMC1168409  PMID: 4462565

Abstract

Thermal-denaturation profiles of helical polynucleotides have been measured in the presence of increasing concentrations of ethidium bromide. The poly(A)·poly(U) helix is strongly stabilized by binding of ethidium, to much the same extent as is DNA, but the stabilizing effect on poly(I)·poly(C) is much smaller. In the poly(A)·2poly(U) system the drug selectively destabilizes and eventually destroys the triple helix, leaving only the double-helix-to-coil transition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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