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. 1998 Oct 1;17(19):5525–5528. doi: 10.1093/emboj/17.19.5525

DNA damage checkpoint in budding yeast.

M P Longhese 1, M Foiani 1, M Muzi-Falconi 1, G Lucchini 1, P Plevani 1
PMCID: PMC1170880  PMID: 9755152

Abstract

Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinate cell-cycle progression in response to internal and external cues. The yeast Saccharomyces cerevisiae has been invaluable in dissecting genetically the DNA damage checkpoint pathway. Recent results on posttranslational modifications and protein-protein interactions of some key factors provide new insights into the architecture of checkpoint protein complexes and their order of function.

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Selected References

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