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. 1999 Jun 15;18(12):3359–3369. doi: 10.1093/emboj/18.12.3359

Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.

U Konietzko 1, G Kauselmann 1, J Scafidi 1, U Staubli 1, H Mikkers 1, A Berns 1, M Schweizer 1, R Waltereit 1, D Kuhl 1
PMCID: PMC1171416  PMID: 10369676

Abstract

In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-1, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long-term potentiation (LTP). Mice deficient for Pim-1 show normal synaptic transmission and short-term plasticity. However, they fail to consolidate enduring LTP even though Pim-2 and Pim-3 are constitutively expressed in the hippocampus and Pim-3 expression is similarly induced by synaptic activity. Thus, expression of Pim-1 is required for LTP. Its level of expression and, consequently, its capacity to phosphorylate target proteins in dendritic and nuclear compartments of stimulated neurons might be a determining factor for the establishment of long-lasting changes in synaptic strength.

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Selected References

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