Abstract
The sequence of photoreceptor outer segment morphogenesis has been studied in the developing kitten retina by the examination of serial ultrathin sections and stereopairs of semithin sections. After the outer segment arose as an expansion of the outer end of the cilium, lamellae which had vertical or near-vertical orientations were formed over the whole surface of the outer segment. Subsequently, lamellae of horizontal orientation were formed at the base of the outer segment. The latter gave risk to a stack of horizontal lamellae which increased in height, so displacing the vertical lamellae further and further from the base of the outer segment. These vertical lamellae were eventually ingested by the pigment epithelium, resulting in outer segments which contained horizontal lamellae only.
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- DE ROBERTIS E. Morphogenesis of the retinal rods; an electron microscope study. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):209–218. doi: 10.1083/jcb.2.4.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DE ROBERTIS E. Some observations on the ultrastructure and morphogenesis of photoreceptors. J Gen Physiol. 1960 Jul;43(6):1–13. doi: 10.1085/jgp.43.6.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOWLING J. E., SIDMAN R. L. Inherited retinal dystrophy in the rat. J Cell Biol. 1962 Jul;14:73–109. doi: 10.1083/jcb.14.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greiner J. V., Weidman T. A. Development of the hamster retina: a morphologic study. Am J Vet Res. 1978 Apr;39(4):665–670. [PubMed] [Google Scholar]
- Greiner J. V., Weidman T. A. Histogenesis of the cat retina. Exp Eye Res. 1980 Apr;30(4):439–453. doi: 10.1016/0014-4835(80)90059-7. [DOI] [PubMed] [Google Scholar]
- Greiner J. V., Weidman T. A. Histogenesis of the ferret retina. Exp Eye Res. 1981 Sep;33(3):315–332. doi: 10.1016/s0014-4835(81)80055-3. [DOI] [PubMed] [Google Scholar]
- Kinney M. S., Fisher S. K. The photoreceptors and pigment epithelium of the larval Xenopus retina: morphogenesis and outer segment renewal. Proc R Soc Lond B Biol Sci. 1978 May 5;201(1143):149–167. doi: 10.1098/rspb.1978.0037. [DOI] [PubMed] [Google Scholar]
- LaVail M. M. Kinetics of rod outer segment renewal in the developing mouse retina. J Cell Biol. 1973 Sep;58(3):650–661. doi: 10.1083/jcb.58.3.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McArdle C. B., Dowling J. E., Masland R. H. Development of outer segments and synapses in the rabbit retina. J Comp Neurol. 1977 Oct 1;175(3):253–274. doi: 10.1002/cne.901750302. [DOI] [PubMed] [Google Scholar]
- Morrison J. D. Postnatal development of the area centralis of the kitten retina: an electron microscopic study. J Anat. 1982 Sep;135(Pt 2):255–271. [PMC free article] [PubMed] [Google Scholar]
- NILSSON S. E. RECEPTOR CELL OUTER SEGMENT DEVELOPMENT AND ULTRASTRUCTURE OF THE DISK MEMBRANES IN THE RETINA OF THE TADPOLE (RANA PIPIENS). J Ultrastruct Res. 1964 Dec;11:581–602. doi: 10.1016/s0022-5320(64)80084-8. [DOI] [PubMed] [Google Scholar]
- Sjöstrand F. S., Kreman M. Molecular structure of outer segment disks in photoreceptor cells. J Ultrastruct Res. 1978 Dec;65(3):195–226. doi: 10.1016/s0022-5320(78)80059-8. [DOI] [PubMed] [Google Scholar]
- Spira A. W. In utero development and maturation of the retina of a non-primate mammal: a light and electron microscopic study of the guinea pig. Anat Embryol (Berl) 1975 May 16;146(3):279–300. doi: 10.1007/BF00302175. [DOI] [PubMed] [Google Scholar]
- Steinberg R. H., Fisher S. K., Anderson D. H. Disc morphogenesis in vertebrate photoreceptors. J Comp Neurol. 1980 Apr 1;190(3):501–508. doi: 10.1002/cne.901900307. [DOI] [PubMed] [Google Scholar]
- TOKUYASU K., YAMADA E. The fine structure of the retina studied with the electron microscope. IV. Morphogenesis of outer segments of retinal rods. J Biophys Biochem Cytol. 1959 Oct;6:225–230. doi: 10.1083/jcb.6.2.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TOKUYASU K., YAMADA E. The fine structure of the retina. V. Abnormal retinal rods and their morphogenesis. J Biophys Biochem Cytol. 1960 Feb;7:187–190. doi: 10.1083/jcb.7.1.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vogel M. Postnatal development of the cat's retina. Adv Anat Embryol Cell Biol. 1978;54(4):1–66. [PubMed] [Google Scholar]
- Vogel M. Postnatal development of the cat's retina: a concept of maturation obtained by qualitative and quantitative examinations. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 8;208(1-3):93–107. doi: 10.1007/BF00406985. [DOI] [PubMed] [Google Scholar]
- Weidman T. A., Kuwabara T. Postnatal development of the rat retina. An electron microscopic study. Arch Ophthalmol. 1968 Apr;79(4):470–484. doi: 10.1001/archopht.1968.03850040472015. [DOI] [PubMed] [Google Scholar]
- Young R. W. Visual cells and the concept of renewal. Invest Ophthalmol Vis Sci. 1976 Sep;15(9):700–725. [PubMed] [Google Scholar]