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. 1976 Jan 15;154(1):141–147. doi: 10.1042/bj1540141

Galactose metabolism in regenerating rat liver.

C H Bauer, B F Hassels, W G Reutter
PMCID: PMC1172685  PMID: 945058

Abstract

1. Rats trained on a controlled lighting and feeding schedule were subjected to partial hepatectomy or sham operation. 2. After a large period of about 6h the activity of UDP-galactose 4-epimerase increased threefold, reaching a maximum 4 days after partial hepatectomy, and returned to normal values within a fortnight. 3. The enzyme pattern of the UDP-galactose-glycoprotein galactosyltransferase was biphasic, one peak appearing at 20 h, the second at 72 h after partial hepatectomy. 4. The rise in enzyme activities could be blocked by the injection of actinomycin D, and the Km values for UDP-glucose and UDP-galactose were nearly identical in regenerating and adult liver. It is therefore concluded that the increase in enzyme activity is due to synthesis de novo of enzyme protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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