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. 1972 Nov;130(2):325–333. doi: 10.1042/bj1300325

Extent and control of antibody diversity.

A R Williamson
PMCID: PMC1174411  PMID: 4124148

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Awdeh Z. L., Williamson A. R., Askonas B. A. Isoelectric focusing in polyacrylamide gel and its application to immunoglobulins. Nature. 1968 Jul 6;219(5149):66–67. doi: 10.1038/219066a0. [DOI] [PubMed] [Google Scholar]
  2. Awdeh Z. L., Williamson A. R., Askonas B. A. One cell-one immunoglobulin. Origin of limited heterogeneity of myeloma proteins. Biochem J. 1970 Jan;116(2):241–248. doi: 10.1042/bj1160241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dreyer W. J., Bennett J. C. The molecular basis of antibody formation: a paradox. Proc Natl Acad Sci U S A. 1965 Sep;54(3):864–869. doi: 10.1073/pnas.54.3.864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Edelman G. M., Gally J. A. Somatic recombination of duplicated genes: an hypothesis on the origin of antibody diversity. Proc Natl Acad Sci U S A. 1967 Feb;57(2):353–358. doi: 10.1073/pnas.57.2.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Eichmann K., Kindt T. J. The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates. J Exp Med. 1971 Aug 1;134(2):532–552. doi: 10.1084/jem.134.2.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Eisen H. N., Michaelides M. C., Underdown B. J., Schulenburg E. P., Simms E. S. Experimental approaches to homogenous antibody populations. Myeloma proteins with antihapten antibody activity. Fed Proc. 1970 Jan-Feb;29(1):78–84. [PubMed] [Google Scholar]
  7. Glazer A. N. On the prevalence of "nonspecific" binding at the specific binding sites of globular proteins. Proc Natl Acad Sci U S A. 1970 Apr;65(4):1057–1063. doi: 10.1073/pnas.65.4.1057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gottesman M. E., Yarmolinsky M. B. Integration-negative mutants of bacteriophage lambda. J Mol Biol. 1968 Feb 14;31(3):487–505. doi: 10.1016/0022-2836(68)90423-3. [DOI] [PubMed] [Google Scholar]
  9. HAYFLICK L. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res. 1965 Mar;37:614–636. doi: 10.1016/0014-4827(65)90211-9. [DOI] [PubMed] [Google Scholar]
  10. Hood L., Eichmann K., Lackland H., Krause R. M., Ohms J. J. Rabbit antibody light chains and gene evolution. Nature. 1970 Dec 12;228(5276):1040–1044. doi: 10.1038/2281040a0. [DOI] [PubMed] [Google Scholar]
  11. Hood L., Talmage D. W. Mechanism of antibody diversity: germ line basis for variability. Science. 1970 Apr 17;168(3929):325–334. doi: 10.1126/science.168.3929.325. [DOI] [PubMed] [Google Scholar]
  12. Kabat E. A. The nature of an antigenic determinant. J Immunol. 1966 Jul;97(1):1–11. [PubMed] [Google Scholar]
  13. Kindt T. J., Mandy W. J., Todd C. W. Association of allotypic specificities of group a with allotypic specificities A11 and A12 in rabbit immunoglobulin. Biochemistry. 1970 Apr 28;9(9):2028–2032. doi: 10.1021/bi00811a026. [DOI] [PubMed] [Google Scholar]
  14. Krause R. M. The search for antibodies with molecular uniformity. Adv Immunol. 1970;12:1–56. doi: 10.1016/s0065-2776(08)60167-4. [DOI] [PubMed] [Google Scholar]
  15. Kreth H. W., Williamson A. R. Cell surveillance model for lymphocyte cooperation. Nature. 1971 Dec 24;234(5330):454–456. doi: 10.1038/234454a0. [DOI] [PubMed] [Google Scholar]
  16. Kuettner M. G., Wang A. L., Nisonoff A. Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains. J Exp Med. 1972 Mar 1;135(3):579–595. doi: 10.1084/jem.135.3.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. LEDERBERG J. Genes and antibodies. Science. 1959 Jun 19;129(3364):1649–1653. doi: 10.1126/science.129.3364.1649. [DOI] [PubMed] [Google Scholar]
  18. Levin H. A., Levine H., Schlossman S. F. Antigen recognition and antibody specificity. Carrier specificity and genetic control of anti-dinitrophenyl-oligolysine antibody. J Exp Med. 1971 Jun 1;133(6):1199–1218. doi: 10.1084/jem.133.6.1199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Montgomery P. C., Rockey J. H., Williamson A. R. Homogeneous antibody elicited with dinitrophenyl-gramicidin-S (rabbit-isoelectric focusing). Proc Natl Acad Sci U S A. 1972 Jan;69(1):228–232. doi: 10.1073/pnas.69.1.228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Pink R., Wang A. C., Fudenberg H. H. Antibody variability. Annu Rev Med. 1971;22:145–170. doi: 10.1146/annurev.me.22.020171.001045. [DOI] [PubMed] [Google Scholar]
  21. SMITHIES O. GAMMA-GLOBULIN VARIABILITY: A GENETIC HYPOTHESIS. Nature. 1963 Sep 28;199:1231–1236. doi: 10.1038/1991231a0. [DOI] [PubMed] [Google Scholar]
  22. Schubert D., Jobe A., Cohn M. Mouse myelomas producing precipitating antibody to nucleic acid bases and-or nitrophenyl derivatives. Nature. 1968 Nov 30;220(5170):882–885. doi: 10.1038/220882a0. [DOI] [PubMed] [Google Scholar]
  23. Szilard L. THE MOLECULAR BASIS OF ANTIBODY FORMATION. Proc Natl Acad Sci U S A. 1960 Mar;46(3):293–302. doi: 10.1073/pnas.46.3.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. TALMAGE D. W. Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept. Science. 1959 Jun 19;129(3364):1643–1648. doi: 10.1126/science.129.3364.1643. [DOI] [PubMed] [Google Scholar]
  25. Tartof K. D. Increasing the multiplicity of ribosomal RNA genes in Drosophila melanogaster. Science. 1971 Jan 22;171(3968):294–297. doi: 10.1126/science.171.3968.294. [DOI] [PubMed] [Google Scholar]
  26. Williamson A. R. Antibody isoelectric spectra. Analysis of the heterogeneity of antibody molecules in serum by isoelectric focusing in gel and specific detection with hapten. Eur J Immunol. 1971 Nov;1(5):390–394. doi: 10.1002/eji.1830010517. [DOI] [PubMed] [Google Scholar]
  27. Williamson A. R., Askonas B. A. Senescence of an antibody-forming cell clone. Nature. 1972 Aug 11;238(5363):337–339. doi: 10.1038/238337a0. [DOI] [PubMed] [Google Scholar]

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