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. 1971 Aug;124(1):13–18. doi: 10.1042/bj1240013

Catalytic activity of α-chymotrypsin in which histidine-57 has been methylated

R Henderson 1,*
PMCID: PMC1177107  PMID: 5126468

Abstract

The properties of a derivative of α-chymotrypsin in which histidine-57 has been methylated have been examined. Although the modified enzyme binds substrate with the same affinity as does native α-chymotrypsin, acylation and deacylation occur at much decreased rates. As for native α-chymotrypsin, a basic group of pKa approx. 7 is involved in both acylation and deacylation. The significance of these results is considered in relation to the normal function of histidine-57.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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