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. 1970 Dec;120(3):601–605. doi: 10.1042/bj1200601

Cellular injury and carcinogenesis. Inhibition of metabolism of dimethylnitrosamine by aminoacetonitrile

L Fiume 1,*, Gabriella Campadelli-Fiume 1,*, P N Magee 1, J Holsman 1
PMCID: PMC1179641  PMID: 5499972

Abstract

1. Aminoacetonitrile, a lathyrogenic agent known to decrease the hepatotoxic action of dimethylnitrosamine, inhibited the metabolism of this compound by rats in vivo and by rat liver slices in vitro. 2. Methylation of nucleic acids in rat liver and kidney by dimethylnitrosamine in vivo was inhibited by treatment of the animals with aminoacetonitrile. 3. These findings are discussed in relation to the hypothesis that dimethylnitrosamine requires metabolism to exert its hepatotoxic and carcinogenic action.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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