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. 1990 Nov;430:595–603. doi: 10.1113/jphysiol.1990.sp018309

Effects of physical training on febrile and acute-phase responses induced in rats by bacterial endotoxin or interleukin-1.

M Wada 1, A Morimoto 1, T Watanabe 1, Y Sakata 1, N Murakami 1
PMCID: PMC1181755  PMID: 2128336

Abstract

1. We investigated the effect of physical training on febrile and acute-phase responses induced in rats by intravenous (I.V.) injection of bacterial endotoxin or human recombinant interleukin-1 beta (IL-1). Physical training was performed by swimming for 1 h per day, 5 days a week. After four weeks of training, animals were used in the experiments. 2. The I.V. injection of endotoxin produced a febrile response in the trained group but not in the control group. However, there were no statistically significant differences between febrile responses induced by the I.V. injection of IL-1 in the control and trained groups. 3. The I.V. injection of endotoxin significantly decreased the plasma concentration of iron and zinc and increased the plasma fibrinogen concentration in both the control and the trained groups. However, the decreases in the plasma iron and zinc concentrations in the trained group were significantly greater than those in the control group. The I.V. injection of endotoxin increased the circulating leucocyte count in the only trained group. 4. The I.V. injection of IL-1 significantly decreased the plasma concentration of iron and zinc and increased the plasma fibrinogen concentration and the circulating leucocyte count in both the control and the trained groups. However, between the two groups, no significant differences in the values of acute-phase reactants were observed. 5. The present results suggest that the ability to produce cytokine(s) to induce febrile and acute-phase responses is enhanced by physical training. However, physical training has no effect on the febrile and acute-phase responses induced by IL-1.

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Selected References

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  1. ATKINS E. Pathogenesis of fever. Physiol Rev. 1960 Jul;40:580–646. doi: 10.1152/physrev.1960.40.3.580. [DOI] [PubMed] [Google Scholar]
  2. Besedovsky H., del Rey A., Sorkin E., Dinarello C. A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 1986 Aug 8;233(4764):652–654. doi: 10.1126/science.3014662. [DOI] [PubMed] [Google Scholar]
  3. Cannon J. G., Kluger M. J. Endogenous pyrogen activity in human plasma after exercise. Science. 1983 May 6;220(4597):617–619. doi: 10.1126/science.6836306. [DOI] [PubMed] [Google Scholar]
  4. Cannon J. G., Kluger M. J. Exercise enhances survival rate in mice infected with Salmonella typhimurium. Proc Soc Exp Biol Med. 1984 Apr;175(4):518–521. doi: 10.3181/00379727-175-41830. [DOI] [PubMed] [Google Scholar]
  5. Chin A. K., Seaman R., Kapileshwarker M. Plasma catecholamine response to exercise and cold adaptation. J Appl Physiol. 1973 Apr;34(4):409–412. doi: 10.1152/jappl.1973.34.4.409. [DOI] [PubMed] [Google Scholar]
  6. Dawson C. A., Horvath S. M. Swimming in small laboratory animals. Med Sci Sports. 1970 Summer;2(2):51–78. [PubMed] [Google Scholar]
  7. Dinarello C. A., Bernheim H. A., Duff G. W., Le H. V., Nagabhushan T. L., Hamilton N. C., Coceani F. Mechanisms of fever induced by recombinant human interferon. J Clin Invest. 1984 Sep;74(3):906–913. doi: 10.1172/JCI111508. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dinarello C. A., Cannon J. G., Wolff S. M., Bernheim H. A., Beutler B., Cerami A., Figari I. S., Palladino M. A., Jr, O'Connor J. V. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med. 1986 Jun 1;163(6):1433–1450. doi: 10.1084/jem.163.6.1433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dinarello C. A. Interleukin-1. Rev Infect Dis. 1984 Jan-Feb;6(1):51–95. doi: 10.1093/clinids/6.1.51. [DOI] [PubMed] [Google Scholar]
  10. Feldberg W., Saxena P. N. Prostaglandins, endotoxin and lipid A on body temperature in rats. J Physiol. 1975 Aug;249(3):601–615. doi: 10.1113/jphysiol.1975.sp011033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harms P. G., Ojeda S. R. A rapid and simple procedure for chronic cannulation of the rat jugular vein. J Appl Physiol. 1974 Mar;36(3):391–392. doi: 10.1152/jappl.1974.36.3.391. [DOI] [PubMed] [Google Scholar]
  12. Helle M., Brakenhoff J. P., De Groot E. R., Aarden L. A. Interleukin 6 is involved in interleukin 1-induced activities. Eur J Immunol. 1988 Jun;18(6):957–959. doi: 10.1002/eji.1830180619. [DOI] [PubMed] [Google Scholar]
  13. Kampschmidt R. F., Upchurch H. F., Eddington C. L., Pulliam L. A. Multiple biological activities of a partially purified leukocytic endogenous mediator. Am J Physiol. 1973 Mar;224(3):530–533. doi: 10.1152/ajplegacy.1973.224.3.530. [DOI] [PubMed] [Google Scholar]
  14. Kluger M. J., Ringler D. H., Anver M. R. Fever and survival. Science. 1975 Apr 11;188(4184):166–168. [PubMed] [Google Scholar]
  15. Kluger M. J., Rothenburg B. A. Fever and reduced iron: their interaction as a host defense response to bacterial infection. Science. 1979 Jan 26;203(4378):374–376. doi: 10.1126/science.760197. [DOI] [PubMed] [Google Scholar]
  16. Kluger M. J., Vaughn L. K. Fever and survival in rabbits infected with Pasteurella multocida. J Physiol. 1978 Sep;282:243–251. doi: 10.1113/jphysiol.1978.sp012460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Moberg G. P. Site of action of endotoxins on hypothalamic-pituitary-adrenal axis. Am J Physiol. 1971 Feb;220(2):397–400. doi: 10.1152/ajplegacy.1971.220.2.397. [DOI] [PubMed] [Google Scholar]
  18. Morimoto A., Murakami N., Myogin T., Takada M., Teshirogi S., Watanabe T. Separate mechanisms inside and outside the blood-brain barrier inducing metabolic changes in febrile rabbits. J Physiol. 1987 Nov;392:637–649. doi: 10.1113/jphysiol.1987.sp016801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Morimoto A., Murakami N., Nakamori T., Sakata Y., Watanabe T. Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin-1. J Physiol. 1989 Apr;411:245–256. doi: 10.1113/jphysiol.1989.sp017571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Morimoto A., Murakami N., Nakamori T., Watanabe T. Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits. J Physiol. 1987 Feb;383:629–637. doi: 10.1113/jphysiol.1987.sp016433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Morimoto A., Murakami N., Takada M., Teshirogi S., Watanabe T. Fever and acute phase response induced in rabbits by human recombinant interferon-gamma. J Physiol. 1987 Oct;391:209–218. doi: 10.1113/jphysiol.1987.sp016734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Morimoto A., Watanabe T., Myogin T., Murakami N. Restraint induced stress elicits acute-phase response in rabbits. Pflugers Arch. 1987 Nov;410(4-5):554–556. doi: 10.1007/BF00586538. [DOI] [PubMed] [Google Scholar]
  23. Ostman I., Sjöstrand N. O., Swedin G. Cardiac noradrenaline turnover and urinary catecholamine excretion in trained and untrained rats during rest and exercise. Acta Physiol Scand. 1972 Nov;86(3):299–308. doi: 10.1111/j.1748-1716.1972.tb05336.x. [DOI] [PubMed] [Google Scholar]
  24. Skarnes R. C., Brown S. K., Hull S. S., McCracken J. A. Role of prostaglandin E in the biphasic fever response to endotoxin. J Exp Med. 1981 Oct 1;154(4):1212–1224. doi: 10.1084/jem.154.4.1212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Stromme S. B., Hammel H. T. Effects of physical training on tolerance to cold in rats. J Appl Physiol. 1967 Dec;23(6):815–824. doi: 10.1152/jappl.1967.23.6.815. [DOI] [PubMed] [Google Scholar]

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