Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1987 Feb;383:629–637. doi: 10.1113/jphysiol.1987.sp016433

Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits.

A Morimoto 1, N Murakami 1, T Nakamori 1, T Watanabe 1
PMCID: PMC1183094  PMID: 3477638

Abstract

1. Intravenous bacterial endotoxin, or endogenous pyrogen, in high concentration both caused biphasic fever in rabbits. In low concentration they produced only the first phase of fever. 2. Subcutaneous indomethacin suppressed the first phase of fever produced by high concentration of intravenous endotoxin or endogenous pyrogen, but not the second phase. 3. Intraventricular cerebral injection of indomethacin reduced the second phase of fever produced by high concentration of intravenous endotoxin or endogenous pyrogen, but not the first phase. 4. Intraventricular cerebral injection of endotoxin or of endogenous pyrogen caused slow monophasic fever. This was suppressed by intraventricular, but not by subcutaneous, indomethacin. 5. It is concluded that the first phase of biphasic fever is caused by pyrogen acting via structures outside the blood-brain barrier, presumably peripheral nerves, and the second phase by pyrogen acting via structures within the blood-brain barrier, presumably hypothalamic neurones.

Full text

PDF
637

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATKINS E. Pathogenesis of fever. Physiol Rev. 1960 Jul;40:580–646. doi: 10.1152/physrev.1960.40.3.580. [DOI] [PubMed] [Google Scholar]
  2. Bernheim H. A., Gilbert T. M., Stitt J. T. Prostaglandin E levels in third ventricular cerebrospinal fluid of rabbits during fever and changes in body temperature. J Physiol. 1980 Apr;301:69–78. doi: 10.1113/jphysiol.1980.sp013189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blatteis C. M., Bealer S. L., Hunter W. S., Llanos-Q J., Ahokas R. A., Mashburn T. A., Jr Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs. Brain Res Bull. 1983 Nov;11(5):519–526. doi: 10.1016/0361-9230(83)90124-7. [DOI] [PubMed] [Google Scholar]
  4. Blatteis C. M., Hunter W. S., Llanos J., Ahokas R. A., Mashburn T. A., Jr Activation of acute-phase responses by intrapreoptic injections of endogenous pyrogen in guinea pigs. Brain Res Bull. 1984 Jun;12(6):689–695. doi: 10.1016/0361-9230(84)90149-7. [DOI] [PubMed] [Google Scholar]
  5. Dascombe M. J., Milton A. S. Study on the possible entry of bacterial endotoxin and prostaglandin E2 into the central nervous system from the blood. Br J Pharmacol. 1979 Aug;66(4):565–572. doi: 10.1111/j.1476-5381.1979.tb13695.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dinarello C. A., Bernheim H. A. Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro. J Neurochem. 1981 Sep;37(3):702–708. doi: 10.1111/j.1471-4159.1982.tb12544.x. [DOI] [PubMed] [Google Scholar]
  7. Feldberg W., Gupta K. P. Pyrogen fever and prostaglandin-like activity in cerebrospinal fluid. J Physiol. 1973 Jan;228(1):41–53. doi: 10.1113/jphysiol.1973.sp010071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fontana A., Weber E., Dayer J. M. Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction? J Immunol. 1984 Oct;133(4):1696–1698. [PubMed] [Google Scholar]
  9. Lin M. T. Effects of intravenous and intraventricular prostaglandin E1 on thermoregulatory responses in rabbits. J Pharmacol Exp Ther. 1978 Jan;204(1):39–45. [PubMed] [Google Scholar]
  10. Milton A. S., Wendlandt S. Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits. J Physiol. 1971 Oct;218(2):325–336. doi: 10.1113/jphysiol.1971.sp009620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Morimoto A., Watanabe T., Ono T., Sakata Y., Murakami N. Rat endogenous pyrogen and fever. Am J Physiol. 1986 May;250(5 Pt 2):R776–R782. doi: 10.1152/ajpregu.1986.250.5.R776. [DOI] [PubMed] [Google Scholar]
  12. Ogawa Y., Kanoh S. Involvement of central action of lipopolysaccharide in pyrogen fever. Jpn J Pharmacol. 1984 Nov;36(3):389–395. doi: 10.1254/jjp.36.389. [DOI] [PubMed] [Google Scholar]
  13. Skarnes R. C., Brown S. K., Hull S. S., McCracken J. A. Role of prostaglandin E in the biphasic fever response to endotoxin. J Exp Med. 1981 Oct 1;154(4):1212–1224. doi: 10.1084/jem.154.4.1212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stitt J. T., Bernheim H. A. Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits. J Appl Physiol (1985) 1985 Aug;59(2):342–347. doi: 10.1152/jappl.1985.59.2.342. [DOI] [PubMed] [Google Scholar]
  15. Stitt J. T. Evidence for the involvement of the organum vasculosum laminae terminalis in the febrile response of rabbits and rats. J Physiol. 1985 Nov;368:501–511. doi: 10.1113/jphysiol.1985.sp015872. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stitt J. T. Prosaglandin E1 fever induced in rabbits. J Physiol. 1973 Jul;232(1):163–179. doi: 10.1113/jphysiol.1973.sp010262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Williams J. W., Rudy T. A., Yaksh T. L., Viswanathan C. T. An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia. Brain Res. 1977 Jan 21;120(2):251–262. doi: 10.1016/0006-8993(77)90904-0. [DOI] [PubMed] [Google Scholar]
  18. du Moulin G. C., Paterson D., Hedley-Whyte J., Broitman S. A. E. coli peritonitis and bacteremia cause increased blood-brain barrier permeability. Brain Res. 1985 Aug 12;340(2):261–268. doi: 10.1016/0006-8993(85)90922-9. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES